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1. ?޺??????̶? ?????ΰ??

2. ?޺????? ???뷮

3. ?޺????? ???ۿ?

4. ?޺????? ?๰ ????

5. ?׾??ۿ뿡 ???? ?޺????? ???ʿ???

6. ?޺??????? ???? ?ΰ??? ?????? ȿ?? ????

7. ?޺????? ?ӻ? ????

8. ?޺????? ?ۿ? ???? 

1. ?޺??????̶? ?????ΰ?? 

?޺?????(Mebendazole, MBZ)?? ?????̴???(Benzimidazole) ?迭?? ?????? ?ۿ??? ?????? ġ????(??????)??. ????, ????, ȸ?? ?? ???? ?????濡 ?θ? ?ۿ??Ѵ?. Vermox(??????, ??????)?? Ovex?? ??ǰ?????? ???̿??? ?θ? ?????Ǿ? ?? ???̴?. ????(?Ϻ?)?????? ?ΰ??Ǿ? ?????? ?????̴?.(?ѱ??????? ?????????? ?????? ?????? ?????? ???? ?ʴ´?.)

2. ?޺????? ???뷮 

1?? 100mg???? ???????? ġ?ῡ?? 1?? 100~200mg?? ??ĥ?? ?????Ѵ?. ?????????? ???Ⱓ ?????Ѵ?. WHO ???̵??????? ????????(cystic echinococcosis, CE)?? 40-50mg/kg/day?? ??? 3~6???? ?????ϰ? ????????(alveolar echinococcosis, AE)???? 40-50mg/kg/day?? 2?? ?̻? ?????Ѵ?. 10?? ?̻? ?????? ???ʺ????? ?ִ?. ?׸?ŭ ???????? ?ſ? ???? ?๰?̶??? ???̴?. 

3. ?޺????? ???ۿ? 

?????? ?ſ? ???? ???ۿ??? ???? ?๰?̴?. ?????? ġ???? ???? ?뷮?? ???????? ???ŵ? ?? ?????̳? ???縦 ????ų ?? ?ִ? ?????̰? ?๰ ??ü?? ?????? ???? ???ٰ? ?????ǰ? ?ִ?. ?׷??? ?幰?? ?˷????? ???????? ?????̳? ?ε巯?Ⱑ ?????? ???쵵 ?ִٰ? ?Ѵ?. ?ӽ? ?߿??? ?????? ?? ????. 2?? ?????? ?ҾƵ? ?????Ͱ? ???? ?????? ???????? ?ʴ´?. 

4. ?޺????? ?๰ ???? 

??ȭ???????? ???????? 20% ?????? ???? ?? 2~4 ?ð? ?? ???? ??? ?????̴?. ?????? ???? ?Ļ??? ?Բ? ?????ϸ? ???????? ????????. 10mg/kg ?????? ?ְ? ?????? ?????? 137.4ng/ml(0.47??M)?̶??? ?????? ?ִ?. 

?ø?Ƽ???? ?޺??????? ?๰???? ȿ?ҿ? ???? ???ظ? ?????ϰ? ???? ??? 1.5?? ???? ???δٴ? ?????? ?ִ?. ?ø?Ƽ?? ??ü?? ?????? ȿ???? ?????Ƿ? ?????ϴ? ???? ?????ϴٴ? ?? ???̴?.(?ø?Ƽ???? ????Ÿ?? ????ü ?????ۿ뿡 ???? ???? ?к??? ?????ϴ? ?๰?? ???? ???̿? ?????? ?????ϴ? ȿ???? ?ӻ????? ??? ??Ÿ????)

5. ?׾??ۿ뿡 ???? ?޺????? ???ʿ???(???缼?? ?? ????????) 

2002?? Mukhopadhyay?? ?????׷?(?ε?)?? ???? ???ϼ????? ?????? ???迡?? ?޺??????? ?뷮 ?? ?ð? ?????????? ???? ?????? ?????Ѵٴ? ?????? ó?? ?????? ?? ?ִ?. 50% ???س???(IC50)?? 0.16??M?̴?. ?? ?????? G2/MѢ???? ?????ֱ⸦ ?????ϰ? ???? ?????? ????Ű?? ?Ǵµ?, ?????? ?ΰ? ???? ???Ǽ????? ?????? ?????Ƽ????? ???ؼ??? 1??M?? ??????? ???????? ?ۿ??? ??Ÿ???? ?ʾҴ?.? 

?? ??, ?޺??????? ?ϼ??? ???? ????ȿ???? ??????, ???Ҿ?, ??????, ?????? ????? Ȯ?εǾ? IC50?? 0.1???? 0.8??M?̾???.

???? ?????? ???? ?㿡 ?̽??? ?????迡?? ?????? ?????? 3mm ???? ?????? ????, ?޺????? 1mg?? ???Ϸ? ?????ϴ? ???? ????? ?뷮 ?????????? ?ϼ????? ???? ???? ?ۿ??? ?????Ǿ???. ??Ÿ ?? ???迡???? ?????? ??????ȿ???? Ȯ?εǰ? ?ִ?. ???? ???????ƿ??? A549 ?????? ?????Ͽ? ?? ???̸? ?????? ???? ????? ???????? ?ϼ????? ?????ϰ? 21?? ???? ?? 300???? ?? ???̰? Ȯ?εǾ????? ?޺????? 1mg?? ???Ϸ? ?????? ???鿡???? ?? ?????? ???? 80% ???ҵ? ?????? Ȯ?εǾ???. ?? ?????迡?? ??Ŭ??Ź???? ??????ȿ???? ?????? ?ʾҴ?. ???? ?? ???????迡?? ???ۿ??? ???? ??Ÿ???? ?ʾҴٰ? ?Ѵ?.

üǥ???????? ȯ???ϸ? 20g?? ???콺 1?? 1mg?????? ü?? 70kg?? ?ΰ??????? 1?? 500mg?? ?ش??Ѵ?. ǥ?? ???緮?? ü???? 3/4??(??Ȯ?ϰԴ? 0.751??)?? ?????Ѵٴ? ??Ģ?? ??????, ?Ϲ??????? ???콺?? ü?? ?? ?????? ?Һ????̳? ?๰?? ???? ?ӵ??? ?ΰ??? ?? 7???? ?˷??? ?ִ?. ???콺?? ???? 1mg/20g?? 50mg/kg, ?ΰ????? 7mg/kg?? ?ش??ϸ? 70kg?̸? 490mg?? ?ȴٴ? ???????? ???????? ?? ġ???? ???? 1?? 500mg ?????? Ÿ???? ?뷮?̶? ?? ?? ?ִ?. 

?׾??? ???? ??????(?Ǽ? ??????) ?????? ?????Ͽ? ?????? ?Ǿ?ǰ?? ?߽????? ?? 2000?????? ȭ?չ??? ??ũ?????? ?????????? 10?????? ?????? ???? ?????ѿ? ?????? ???? ?ʰ? ?Ǽ? ?????? ?????? ?????? ?????Ͽ??? ?? ?? 4 ?????? ?????̴̹???(benzimidazoles)?? ?????̾???. ?? 4???? ?޺?????(mebendazole), ?˺?????(albendazole), ?溥????(fenbendazole), ???ú?????(oxybendazole)?̾??? ?? ??? ?޺??????? ???? ?׾?ȿ???? ???Ҵ? ?????? ?????? ?? ?ִ?.

?޺??????? 2?????? ?׾??? ?????? ?Ǽ? ?????? ?????ֿ? ???? ?뷮 ?????????? ?????? ?????ϴ? ?ۿ??? ??Ÿ?°? IC50?? ???? 0.32??M?̾???. ????, ?????缺 ?????? ?????ֿ? ???? IC50?? 1.9??M?̾???.

?ΰ? ?Ǽ? ?????? ?????? ???? ??(?鿪 ???? ??)?? ?̽??? ????????? ?޺??????? 1mg?? 2mg?? ???Ϸ? ?????ϸ? ?????? ?????? ??Ʈ??(?޺????? ??????)?? ???쿡 ???? 1mg?? ???? 83%, 2mg?? 77%?? ???? ?????? ?????Ǿ???. ?̰??? 100mg/kg?? temozolomide(?׾???, ??ǰ?? : ?׸???)?? ?????? 5?? ???? ?????? ?Ͱ? ȿ???? ?????ߴ?. Temozolomide?? ?Ǽ? ???????? ġ?ῡ ǥ?????? ?????Ǵ? ?׾????? ?? ?????????? ?缺 ?????????? ?????ϰ? ?ִ?. ?̴? ?Ǽ? ???????? ???? ?޺??????? ??????ȿ???? ???뷮?? Temozolomide ?????? ?????ϴ? ??????, ?Դٰ? ???ۿ??? ???? ???ٴ? Ư¡?? ??Ÿ?´?(Mol Cancer Res. 6 (8) : 1308-1315, 2008). 

?? ???迡?? ?????? ?Ǽ? ???????? 2???? ?????ִ? ?׸????ι̵??? ?ý??ö?ƾ?? ????????, ?ϳ?(M-14)?? ?????? p53?? ??????, ?ٸ? ?ϳ?(SK-Mel-19)?? ???????? p53?? ???? ?????̴?. ?????? ?? ?? ?????ֿ? ???? ??????ȿ???? ??Ÿ?? ???? ?޺??????? ?׾??? ???????? ?? ???? ?????? p53?? ???? ?????? ???????? ??????ȿ???? ??Ÿ???? ???? ?ǹ??Ѵ?. 

???? ?? ?????? ?޺??????? Bcl-2 ?ܹ????? ?λ?ȭ?Ͽ? ?ϼ????? ?????? ?????ϴ? ??Ŀ?????? ?????ϰ? ?ִ?. Bcl-2?? ???????̳? Ȱ???? ?????ϴ? ġ???????? ???뿡 ???? ?޺??????? ??????ȿ???? ???? ???ɼ??? ?û??? ?ִ? ???̴?.

?????? ?Ű汳??(glioblastoma multiforme)?? ???? ?޺??????? ȿ???? 2011?⿡ ?쿬?? ?߰ߵǾ???. ?׸??????????丶?? ?̽??? ?㸦 ?̿??? ???????? ???? ?????? ?????? ?????? ???????? ?溥????(Fenbendazole)?? ?????? ?㿡?? ?̽??? ?????? ???????? ???? ?????? Ȯ?εǾ???. ?溥?????? ?????? ?????Ǵ? ?????̴̹??? ?迭?? ???????? ?????̴?. 

???? ?????? ?????Ͽ?, ?????̴̹????? ?๰ ?? ?޺??????? ???? ?????ϰ? ?׸??????????丶?? ?????? ?????ϴ? ?????? ????????. ???缼?? ???迡???? ???? ?Ű汳?? ?????? GL261?? ???? ?޺??????? 50% ???ľ??? ????(IC50)?? 0.24??M, ?ΰ??? ?׸??????????丶 ??????(060919)?? ???? IC50?? 0.1??M?̾???. ?׸??????????丶 ?????? ?㿡 ?̽??ϴ? ???????迡?? ?޺??????? ?汸 ????(50mg/kg)?? ?????ϰ? ?????Ⱓ?? ??????Ų(63% ????) ?????? ??Ÿ????(Neuro oncol 13 (9) : 974-982. 2011??).

?????Ͽ? ȿ?????? ?׾Ϲ????? Ž???????? ?޺??????? ?ĺ? ?????? Ȯ?εǾ???. ?? ?????????? 1600?????? ???? ?Ǿ?ǰ?? 2?????? ?????? ??????(HCT116?? RKO)?? ?????Ͽ? ?? ?׾? ?ۿ??? ?????Ǿ? 64?????? ?????? ?ĺ??? ?ö???. ?? ?ȿ? ?????̴???(benzimidazoles)?? ?๰ ?˺?????(albendazole), ?޺?????(mebendazole), ???ú?????(oxybendazole) ?溥????(fenbendazole)?? ?????ְ? Ư?? ?޺??????? ?˺??????? ??????ȿ???? ?????Ǿ???. ?? ?? ?????? ???õ? ?????? ?̹? ?Ǿ?ǰ???? ???ε? ?? ???? ?Ǿ? ?ӻ????迡 ?ٷ? ?????? ?? ?ֱ? ?????̾??ٰ? ?Ѵ?. 

??????, ??????, ??????, ?Ǽ? ???????? ?????? ?????? Ȱ???? ??Ÿ?´?. 

?????? ?????ֿ? ???ؼ??? 80%?? ?????ֿ? ???? ?޺??????? ??????ȿ???? ??Ÿ?´?. 5?????? ?????? ??????(HCT 116, RKO, HT29, HT-8 and SW626)?? ?̿??? ???????? IC50?? ???? ?????? ?????????? 5??M ???Ͽ???, ?????????? ???ؼ??? ???? ?????? Ȯ?ε??? ?ʾҴ?.

?׾??? ???? ?????? ??????(SKBr-3)?? ?̿??? ?????????? ?????̴̹????? ?๰?? ?????? ?????ϴ? ȿ???? ??Ÿ?´?. ?޺??????? ???? ???? ??????ȿ???? ??????, 0.5??M ????? ?????? ?????? ???????? 63.1% ???ҽ??״?.(J Clin Exp oncol 02 (02) DOI : 10.4172 / 2324-9110.1000109)

?? ?????? ?????? ?̿??? ?????????? ?޺??????? ?ӻ??????? ?????? ?? ?ִ? ????? ?????? ?????? ?????ֱ⸦ ???????? ?????????? ?????ߴ?. 

6. ?޺??????? ???? ?ΰ??? ?????? ȿ?? ???? 

?޺??????? ?ΰ??????? ?????? ȿ???? ???? ?ӻ??????? ?????? ???????????? ???? ?????ǰ? ???? ?????? ?ΰ? ?????? ?????? ?ִ?.

?? ???̵? ?ν????????? ???Ⱓ ?????? ???ʰ? 2011?⿡ ?????Ǿ???.

?ν????????? ?幮 ?Ǽ? ???????? ?????? ?? ???? ???쿡?? ȿ?????? ġ?????? ???? ???ٰ? ?Ѵ?. ?? ???ʿ????? ???? ?׾??? ġ?Ḧ ?޾????? ȿ???? ???????? ?ʰ? ?????Ǿ???. ?ٸ? ġ?????? ???? ?ܰ谡 ?Ǿ?, ȯ?ڴ? Pubmed ???? ?˻????? ?ν??????Ͽ? ?޺??????? ??????ȿ???? ??Ÿ???ٴ? ???ӻ? ?????????? ã?Ҵ?. ?׸??? ??ġ?ǿ? ?????Ͽ? ???? ?????? ?????? ?????? ???????? ???ٴ?(???? ????) ???????? ?޺??????? ?????ϰ? ?Ǿ???.

?޺??????? 1ȸ 100mg?? 1?? 2ȸ ?????ϴ? ?????? ġ???? ǥ?? ?????? ?????Ͽ? ?????? ?????ߴ?. ?????? ?????Ͽ? ?????? ???Ҹ? ?????ϰ? 19???? ???? ???? ????(???? Ŀ???? ?ʴ?)?? ?????Ǿ???. 

???ۿ??? ???? Ȯ?ε??? ?ʰ? ???? ??(QOL)?? ù ??° ???? ?? ???ر??? ?????Ǿ???. ?׷??? ?޺????? ?????? ?????ϰ? 24???? ?Ŀ? ?????? ?????? Ȯ?εǾ? ?????θ?????(everolimus)?? ?߰???????, ȿ???? ??Ÿ???? ?ʾҴ?.(Endocr Prac 17 (3) e59-62 DOI : 10.4158 / EP10390.CR)

?? ?ٸ? ???? ???????? ???̿? ?޺??????? ?????? ???ʰ? 2013?? ?????Ǿ???. 

74?? ?????? ???̵? ???༺ ?????Ͽ??? ???? ?׾????? ī????Ÿ?? + ??Ű?縮????ƾ + bevacizumab?? ?̿??????? ȿ???? ????, ī????Ÿ?? + ?̸?????ĭ???? ġ???ϰ? ?Ǿ???. ?? ?? ǥ??ġ?? ȿ???? Ȯ?ε??? ?ʴ? ?ܰ迡?? ?޺??????? ?????Ǿ???. ?޺????? ?ܵ? ?????? 6?? ???? ?? CT?˻翡?? ???? ?????? ?????? ???? ???صǾ??? ?? ???̵? ?????? ???ҵ? ?????? ??Ÿ????. ?׷??? ?? ?????? ??ȭ?Ǿ?(AST?? ALT?? ????) ?Ͻ??????? ?޺????? ?????? ?????ϰ? ?? ?????? ȸ???ϰ? ???? ???????? ?ٿ? ?簳?Ͽ???. CT?˻翡?? ?????? ???Ұ? Ȯ?εǾ???. ġ?Ḧ ?ߴ??ϰ? 3?????? ???? ?? ?? ???̰? Ȯ?εǾ? ???缱 ġ?Ḧ ?޾Ұ? ?????? ???̰? ?????߱? ?????? ?޺??????? ȿ???? Ȯ???? ?? ???ٴ? ?Ǵܿ??? ġ?Ḧ ?????Ͽ???. ???? 5???? ?޺????? ġ?Ḧ ?޾? 1?ʿ??? ?κ? ???Ұ? ?????Ǿ???.(Acta oncol 57 (3) 427-8, 2013 ??)

7. ?޺????? ?ӻ? ???? 

?? ġ?ῡ?? ?޺??????? ȿ???? ?????ϴ? 2???? ?ӻ??????? ???? ???? ???̴?. ???? ?????? ?????ڵ??̴?. ?ϳ??? ????ȩŲ?????п??? ?̷??????? ?????? ?׸????θ??̵? ġ?? ???? ???? ?Ǽ??? ?????????? ȯ?ڸ? ???????? ?? ??1?? ???Ͱ? ????. 1?? 1500mg(500mg?? ?޺????????? 1?? 3ȸ ????) ?׸????θ??̵??? ?????? ?????? ???뷮 ???? ?? ??ȿ?? ???䰡 ?????̴?. 

?? ?ٸ? ?ӻ? ?????? ???? ???? ?Ҿ??ǷἾ??(Cohen Children 's Medical Centre)???? ???? ???? ?׸????? ???????? ??ũ????ƾ, ī???ö?ƾ, ?׸????θ??̵??? ?Բ? ?????ϴ? ??1??, ??2?? ?????????̴?. ???뿡 ???? ġ?? ȿ???? ?????????? ???θ? ?????ϴ? ???̴?. 100mg?? 1?? 2ȸ, 70?? ?̻??? ġ?? ?Ⱓ???? ?Ͽ? ?????ǰ? ?ִ?. 

8. ?޺????? ?ۿ? ???? 

???????? ??????Ű?? ?ۿ????????? Ʃ?θ?(tubulin)?? ?????? ?????Ͽ? ???? ?п??? ?߿??? ?????? ?ϴ? ?̼??Ұ??? ?????? ?????ϴ? ȿ???? ?????ǰ? ?ִ?. ?̼??Ұ? ???????δ? ??Ŭ??Ź??(??ǰ??; Ź??)?? ??ũ????ƾ ???? ?ִ?. ??Ŭ??Ź??(paclitaxel)?? Ʃ?θ??? ?????? ?????????ν? ?̼??Ұ?(microtubule)?? ????ȭ?Ͽ? ?ϼ????? ?п??? ?????Ѵ?. 

?̼??Ұ??? ???? ???? Ʃ?θ??? ?̷?ü?? ?????Ǹ? Ź???? ?? ?? ??-Ʃ?θ??? ?????Ͽ? ?????? ?????????ν? ?׾??ۿ??? ??Ÿ????. ????, ?޺??????? Ʃ?θ??? ?????Ͽ? ?̼??Ұ??? ?????? ?????Ѵ?. ?޺??????? Ʃ?θ??? ????ģ ???? ?????ο? ?????Ѵ?. 

*?̼??Ұ??? ??-Ʃ?θ??? ??-Ʃ?θ??? ?????? ?????̷?ü(???׷? ???̸?)?? ?⺻?????? ?????Ǹ?, Ʃ?θ? ?????̷?ü?? ???????? ?????? ???? ?????? ?ʶ???Ʈ?? ?ϰ?, ?̰??? 13?? ???? ?????? ????(???? 25nm)?? ???? ???? ?̼??Ұ??̴?. 

???? ?п??? ?̷????? ?? ???? ?????? DNA?? ?????ǰ? ?????? DNA?? ?̼??Ұ??? ?̲??? ?п? ?? ?????? ?????? ?????? ?ȴ?. ?޺??????? Ʃ?θ??? ?????Ͽ? ?̼??Ұ??? ?????? ?????Ͽ? ???? ?п??? M?⸦ ???????? ???? ?????? ????Ų??. 

???뷮?? ?????ϸ? ???ۿ????? Ż??, ????, ?ε巯??, ???? ????, ?????? ???Ұ? ?߻??? ?? ?ִ?. ?׷??? ?ٸ? ?̼??Ұ? ??????(ŸŰ???質 ??ī ??Į???̵?)???? ?? ?? ?ִ? ???ʽŰ? ?????? ?????? ????. Ʃ?θ??? ????ģ ???? ?????ο??? ?????? ?Ű????ָ? ???????? ?ʴ? ?????? ?˷??? ?ִ?. 

?̼??Ұ? ???? ?̿??? ?ۿ??????? ???ؼ??? ?????ǰ? ?ִ?. ?? ???? ?????? p53 ?????? ?????? ???????? ?????? ?????Ѵٴ? ?????? ??????, p53?? ???????? ?ϼ????? ???̵? ?ϼ??????? ?????? ?ۿ??? ??Ÿ???? ?????? ?????Ǿ???.

???? ?Ż? ???? ?ۿ뿡 ?????Ѵٴ? ?????? ?ִ?.

?̼??Ұ? ???????? ŸŰ???質 ??ī ??Į???̵带 ???뷮???? ??Ʈ?γ??Ϳ? ?????ϸ? ?鿪?? Ȱ??ȭ?ϴ? ?ۿ??? ?ִ?(*???뷮?? ???? ???? ?????ϴ? ?׾??? ġ???? ??Ʈ?γ??? ?ɸ??׶???(Metronomic Chemotherapy)???? ?Ѵ?). ?޺??????? ???? ?鿪 ?????ۿ??? ?û??ȴ?.

?޺??????? ?????????? Ʃ?θ??? ????ģ ???? ?????ο? ?????Ͽ? ?̼??Ұ? ?????? ?????ϰ? ???ۿ??? ???? ?????? ?뽺ī???? ?ִ?. ?뽺ī???? ??༺ ???߼? ???ذŴ????̴?. ?뽺ī???? ???? ?Ż? ???? ?ۿ? ???? ?????? ȿ???? ?????ǰ? ?ִ?.

?Ǽ? ?????? ?????? ?????? ???迡???? ?????????? ?????ϴ? Bcl-2 ?ܹ????? ?λ?ȭ?Ͽ? ??Ȱ???ϰ? ?????????? ?????ϴ? Bax?? Ȱ??ȭ?Ͽ? ?????????? ????Ű?? ?ۿ??? ?????ǰ? ?ִ?. Bcl-2 Bax?? ???? ?????Ͽ? ?????????? ?????Ѵ?. Bcl-2 ?ܹ????? ?λ?ȭ?Ǹ? Bax?? ?????ϰ? ?ǰ?, Bax?? ?ٸ? Bax?? ȣ?????̸Ӹ? ?????ϰ? ?Ǹ? ?????????? ?????ȴٴ? ??Ŀ?????̴?.(Mol Cancer Res. 6 (8) : 1308-1315, 2008)

*Bcl-2?? Bax?? ?????Ͽ? Bax?? ?̷?ü?? ???????? ???ϰ? ?Ͽ? ?????ܵ帮?? ???? ???????? ?????????ν? ?????????? ?????Ѵ?. ?޺??????? Bcl-2 ?ܹ????? ?λ?ȭ?Ͽ? ??Ȱ??ȭ?Ѵ?. ?? ???? ?????ϰ? ?? Bax?? ?????ܵ帮?? ?ܺ? ?????? ?̷?ü(???̸?)?? ?Ǿ? ?????? ?????Ͽ? ?????ܵ帮?ƿ??? ????ũ?? C?? ?????? ?پ??? ?ܹ????? ???????? ?????ϰ? ?ܹ??? ????ȿ?? ī???ľ???(Caspases)?? Ȱ??ȭ?Ǿ? ?????????? ?????ȴ?. 

?޺??????? ?߽????? ??Ʈ?γ??? ?? ?ɸ??׶???(?汸 ??Ŭ???????Ĺ̵??? ???뷼???? ???뷮 ????), ??Ŭ???䳫(??ǰ?? ????Ÿ??), ?????۽ú?(??ǰ?? ?????۽?), ??Ʈ??????(??ǰ?? ?????׷???) ?? ???ۿ??? ???? ?????ϸ鼭 ?????? ȿ???? ?????? ?Ǿ?ǰ?? ?????ϸ? ?????? ȿ???? ?????? ???ɼ??? ?????ǰ? ?ִ?. 

*?޺??????? VEGF ????ü?? Ű???? Ȱ???? ?????Ͽ? ???? ?Ż??? ?????Ѵ? 

???? ???Ǽ??? ???????? ????ü(Vascular Endothelial Growth Factor Receptor, VEGFR)?? ???? ???Ǽ??? ???? ????(VEGF)?? ???????? ?ϴ? ????ü?? Ƽ?ν?Ű?????? ???????? ???? ???Ǽ????? ???İ? ???? ????, ???? ?????? ???? ? ?????Ѵ?. ?ϼ????? ???? ?????? ???ҿ? ?????? ?????ϴ? ?????? ?ø??? ???? VEGF?? ?????? ?????Ѵ?. VEGF?? ???? ???Ǽ????? VEGFR?? ?ڱ??Ͽ? ???? ?Ż??? ?????Ѵ?.? 

??????, VEGF ????ü?? Ȱ??ȭ?? ?????ϴ? ?ۿ??? ???? ?Ż??? ?????ϴ? ?ۿ??? ?־? ???? ?????? ?????? ?????ϰ? ???̸? ?????ϰ? ?ȴ?. VEGFR???? ?? ???? ???̼????? ?ִµ?, ???? ?Ż??? ???? ũ?? ?????ϴ? VEGFR-2?? Ƽ?ν?Ű???? Ȱ???? ?????ϴ? ?ۿ??? ?޺??????? ?ִٰ? ?????ǰ? ?ִ? . 

*???? ???Ǽ????? ???? ???Ǽ??? ???????? ????ü-2(VEGFR-2)?? ???? ???Ǽ??? ????????(VEGF)?? ?????ϸ? VEGFR-2?? ?̷?ü?? ?????ϰ? ???? ?? Ƽ?ν?Ű???? ?????ο? ?????ϴ? Ƽ?ν? ?ܱ??? ?ڱ??λ?ȭ?? ?߻?, ???? ?? ??ȣ???ް谡 Ȱ??ȭ?Ǿ? ???? ???Ǽ????? ???? ?? ???? ?????? ?????Ǿ? ???? ?Ż??? ?????Ѵ?. 

?? ?????? ?????ϱ? ???? VEGF?? ?к??Ѵ?. ???? ?????? ?????ϴ? ?????? ?????? ???İ? ???̰? ?????ȴ?. ?޺??????? VEGFR-2?? Ȱ??ȭ?? ?????Ͽ? ???? ?Ż??? ?????Ѵ?. 

?Ǿ?ǰ?? ?簳??(Drug Repositioning)?? ???쿡??, ????ü?? ???????? ?? Ÿ???? ?Ǵ? ???? ?? ?????? ???? ?????? ?????? ?Ǿ?ǰ?̳? ???? ???? ȭ?չ??? ???? ?????? ?????? ??ǻ?Ϳ??? Ȱ???? ?????ϴ? ???????? Ž???? ?̷???????. ?̷??? in silico(??ǻ?? ?ӿ???)?????? Ž?? ???????? ?޺??????? VEGFR-2?? ?????Ͽ? ?? Ȱ???? ?????ϴ? ?ۿ??? ?ִٰ? ?????ǰ? ?ִ?.

?׸??? ?????? ???? ???Ǽ????? ?????? ???迡?? ?޺??????? VEGFR-2?? ?????Ͽ? ?? Ȱ???? ?????ϰ? ???? ???Ǽ????? ???İ? ???? ?? ???? ?Ż??? ?????ϴ? ???? Ȯ?εǰ? ?ִ?(J Cancer Res Clin oncol 139 : 2133-2140, 2013). 

???? ?޺??????? ???? ??Ȱ?? ?????? ?????? ?????ϴ? ȿ???? ?????Ǿ???. ?????? ???? ?????? ?װ??̴?. 

Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice (?޺??????? ???콺?? ???? ?ջ??? ???? ?Ͼ ???? ??Ȱ?? ?????? ???İ? ?Ż? ???? ?????? ?????Ѵ?) PLoS one 2014 Feb 27; 9 (2 ) : e90146. doi : 10.1371 / journal.pone.0090146. eCollection 2014. 

?޺??????? ???????? ?̼??Ұ??? ?????? ?????????ν? ?? ??ȿ?? ???ֵȴ?. ???? ??Ȱ?? ?????? ???????? ???? ???? ?????? ġ?ῡ ?޺??????? ??ȿ???? ?????? ???????? ???? ?????? ?????? ???????? ???콺?? ?????? ?ջ??? ?????迡?? ???? ??Ȱ?? ?????? ???Ŀ? ???? ?޺??????? ȿ???? ?????ߴ?.

???콺 ???? ??Ȱ?? ?????? ?̿??? ???迡???? ?޺??????? ??Ȱ?? ?????? ???İ? ?̵??? ?????ϰ? ?? ?ۿ??? ???? ?? ?̼??Ұ??? ?????? ??ȭ?? ?????? ?ִ?. ??ü ???????? ???? ??Ȱ?? ?????? ???? ?ۿ??? ?????ϱ? ???? ?޺??????? ?????? ???콺?? ?????? ??(??Ʈ??)???? ??????? ???̾??? ??ó?? ???? ???? ??ȭ?? ?????ߴ?. ???? ?ջ? ?? ???? ??Ȱ?? ?????? ???İ? ?̵? ?? ?Ż? ?????? ?????? ?޺????? ???? ?㿡???? ?????? ?㿡 ???? ?????Ǿ???. 

?????? ?????? ?ջ??? ?????? ??ó?? ?????ϴ? ???????? ??Ȱ?? ?????? ?????ϰ? ?Ż? ?????? ?????? ?Ͼ??. ?㸦 ?????? ???迡???? ???? ????ƿ? ???̾??? ?λ??? ???? ?????????? ???? ?????ȴ?. ?? ?????????? ???? ??????? ???̾??? ??ó?? ???? ?????迡?? ?޺??????? ??????Ű?? ???? ??Ȱ???? ???İ? ?Ż? ?????? ?????? ?????ȴٴ? ???̴?. ?????? ?޺??????? ???ư?ȭ ?? ???? ??Ȱ?? ?????? ???Ŀ? ?????ϴ? ???? ??ȯ?? ġ?ῡ ?????????? ??ٴ? ?????? ?????̴?.

?޺??????? ???? ???Ǽ??? ?Ӹ? ?ƴ϶? ???? ??Ȱ?? ?????? ???ĵ? ?????ϹǷ? ȿ?????? ???? ?Ż? ?????ۿ뿡 ???? ?????? Ȱ???? ?????? ?? ?????? ?û??ϰ? ?ִ?. 

?̻? ?ֱ? ???????κ??? ?޺??????? ?? ??ü???п? ?ٷ? ?????? ???? ?ٰŸ? ???´ٰ? ???? ?? ???? ???̴?.

???? ???? 

Repurposing Drugs in oncology (ReDO) -mebendazole as an anti-cancer agent(?????п??? ?Ǿ?ǰ?? ???? ?? ???? : ?׾????μ??? ?޺?????), 

Ecancermedicalscience 2014; 8 : 443.Published online Jul 10, 2014 . doi : 10.3332 / ecancer.2014.443 

*?޺??????? ?????? ?? ġ?? ???? 

-?޺??????? ?Ϸ翡 ü?? 1kg?? 5~10mg?? ???????? ?????Ѵ?. ?޺????? 1???? 100mg?̴?. ó?????? 1?? 2??(200mg)???? ?????ϰ? ?????? ?????? 1?? 3-6?????? ?ø????? ?Ѵ?. 

-???Ŀ? ?????Ѵ?. ?⸧?? ???? ?????? ???? ȿ???? ?????ش?. 

-?ø?Ƽ???? 1?? 400~800mg ?????Ѵ?. ?ø?Ƽ???? ?? ??ü?? ?????? ȿ???? ??Ÿ?????? ?޺??????? ???ظ? ?????Ͽ? ???? ??? ???̴? ȿ???? ?ִ?.