ATA :: Advances Test of Attention

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?̾??? 18???̸??ǻ??????Ի????ؼ??¾ȵȴ١?

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1.????

1???̾????????ϰ????ϴ?ȯ?ڴ¾ฮ?????ο??????????ϱ????????߱????????????ϰ??????????αٿ????ο??????????ϱ????Ͽ????к??£?medical history??????ü?˻磨physical examination?????ǽ??Ͽ????Ѵ١?

2?????????μ??ݵǴ½??忡???????輺???ֱ⶧???????߱???????????ġ?Ḧ?????ϱ????????ǻ???ȯ???ǽ????????¸??????Ͽ????Ѵ١????????????????Ľ?????????ȯ?????õ?????????????ȯ?ڴ´??̻??Ǽ????????ﰡ?????̸??ǻ翡?Ծ˷????Ѵ١?

3???̰迭?Ǿ๰???? 4?ð??̻??????ӵȹ߱??????ӹ߱?????6?ð??̻??????????????ѹ߱⣩?̵幰?Ժ????Ǿ??١? 4?ð??̻??߱Ⱑ???ӵɰ????????ǻ??ǵ?????medical assistance???????϶???ȯ?ڿ??Ծ˷??־????ϸ磬???ӹ߱?????????ġ???????????????????????Ǽջ??׹߱????ǿ??????????ʷ??Ҽ??ִ١?

4???̾????????ϱ????̳??????ϴµ??ȹ????????ĸ????????????꿰?????Ǵ? NO ??????????Ʈ?α۸????????ƹг???Ʈ????Ʈ???????̼ҼҸ????壩???????ϴ°??????а????ۿ????????Ǿ??????ϰ??????̶????????????Ƿ??ǻ????̾???ó???ϱ?????ȯ?ڰ????꿰?????? NO ?????????????????ʾҴ?????????Ȯ???Ͽ????ϸ磬?̾??????߹??????????꿰?????? NO ?????????????????ʵ??????ǽ?Ų?١?

5???ɱٰ??????޼??????????Ҿ?????????????unstable angina pectoris?????ɽǺ????ƣ?ventricular arrhythmia?????????ߣ????ϰ????????????ۣ?transient ischemic attacks???????룬?ɰ????????????????????ߴ??ѽ??????????ػ??ʣ?cardiovascular events?????̾????ӻ????/?Ǵ½??????????߿??߻??Ͽ??١??????ӻ????迡???????а??????У?ü?????????????ԣ????幰?Գ?Ÿ???١??̷??????ػ??ʵ??̳?Ÿ??ȯ?ڵ??Ǵ??κ??????????ͽ??????????????ڵ飨pre-existing cardiovascular risk factors???????????־??١??׷??????̷??????ػ??ʵ??̽??????????????ڵ??Ǵ??̾??Ǵ¼??????Ǵ??̷??????ڵ??????նǴ´ٸ????ڵ??????????ο??????ִ????ºи????????????ʾҴ١?

6??Ÿ?ٶ????? 612?????????? 25mg/kg/?ϣ?20mg?Ǵ?ȸ?뷮??????????ü?????????ȳ??⺸???ּ??? 3?踦?Ѵ³??⡼???? 3.718.6] ?????ʷ????ױ??̻??ǿ뷮???ΰ????????????????Ϻΰ???????????????spermatogenesis???ǰ??Ҹ??????????????????ǣ?seminiferous tubular epithelium???????ࣨregression?????־??١?

?̾?????????????spermatogenesis???????????????ο??????????ϱ????أ????๰ 10mg?? 6?????????Ϻ????ϰų??? 20mg?????? 6?????Ǵ? 9?????????Ϻ????ѳ????鿡?? 3?????ӻ?????̽ǽõǾ??١????? 2???ǿ???????Ÿ?ٶ?????ġ???Ͱ????Ͽ??ӻ???Ÿ?缺??????̴????ڼ??ڿͳ????ǰ??Ұ??????Ǿ??١????ڿ???????£??????ڱ?ȣ??????follicle stimulating hormone???Ǵٸ?ô?????Ǻ?ȭ?°????????ʾҴ١?11. 1??????????Ư??????????.

7???½ɽ????????????? : ?뵿??????????Ư?߼????ļ??뵿?????Ϻ????????????ִ?ȯ?ڴ? PDE5 ??????????????????Ȯ???????ۿ뿡?ΰ??Ҽ??ִ١?

2.????ȯ?ڿ???????????????

1??????????????????꿰??organic nitrate??????????????????/?Ǵ°????????κ????ϴ?ȯ?ڿ??Դ??̾??????????ݱ??̴١?1.?????? 6.??ȣ?ۿ?????????.?ӻ????迡??Ÿ?ٶ??ʣ?tadalafil???????꿰??nitrate???????????ۿ?????????Ű?°????γ?Ÿ???١?Ÿ?ٶ?????????Ȯ?强?????????ǷΣ??Ͻ??????????????ణ???ҽ?Ű?硼11. 1??????????Ư???????????װ??????꿰???????????ۿ?????????Ų?١??̰??????һ?ȭ????nitric oxide??/cGMP ???ο????????꿰??Ÿ?ٶ????Ǻ???ȿ???ǰ??????Ǵܵȴ١?

2???̾????????ѹ߱???????erectile dysfunction????ġ???ϴ¾๰?????????????????????ʴ½?????ȯ??cardiac disease?????ִ³??????Ի????ؼ??¾ȵȴ١??ǻ??????????ͽ?????????ȯ???ִ?ȯ?ڿ??????????????????????ν??????裨cardiac risk?????????Ͽ????Ѵ١?

3????????????ȯ???ִ´?????ȯ?ڱ????ӻ????迡???Ե????ʾ????Ƿ??̾??ǻ????̱ݱ??̴١? :

?ֱ? 90???̳????ɱٰ?????myocardial infarction?????־???ȯ??

?Ҿ?????????????unstable angina???Ǵ¼?????sexual intercourse???߿??߻???????????angina?????־???ȯ??

?ֱ? 6???????? New York Heart Association Class 2 ?Ǵ±??̻??ǽɺ?????heart failure?????־???ȯ??

?????????ʴ£?uncontrolled???????ƣ?arrhythmias?????????У???90/50mmHg?????Ǵ??????????ʴ°????У???170/100mmHg??ȯ??

?ֱ? 6?????̳????????ߣ?stroke?????־???ȯ??

4?????Ҽ??????????????Ͽ??̹̾˷??????????????༺??????ȯ?ڴ??ӻ????迡???Ե????ʾ????Ƿ??̾??ǻ????̱????????ʴ´١?

5???̾???Ÿ?ٶ????̳??̾??Ǽ??п?????????hypersensitivity?????ִ?ȯ?ڿ????????ϸ??ȵȴ١?

6???̾????ٸ??߱?????ġ???????Ǻ??뿡???Ѿ?????????ȿ???̿????????ʾ????Ƿδٸ??߱?????ġ???????Ǻ????????±????????ʴ´١?

7???̾??????????????ϰ??????ǷΣ????????????ҳ?????galactose intolerance???? Lapp ????????ȿ?Ұ???????Lapp lactase deficiency???Ǵ???????~?????????????????֣?glucose-galactose malabsorption?????????????ι??????ִ?ȯ?ڿ??Դ??????ϸ??ȵȴ١?

8???????? PDE5 ?????????뿩?οͰ??????̺?????????????ýŰ?????Non-arteritic anterior ischemic optic neuropathy, NAION?????????????ʴ??ǽ÷??̼սǵ?ȯ?ڿ??Դ??̾????????ϸ??ȵȴ١?

9???̾????????? PDE5???????? GC ?ڱ?????Guanylate Cyclase Stimulator?????????????ñ??ѣ????????????ϴ°??죬 GC ?ڱ?????Guanylate Cyclase Stimulator???????а???ȿ??????????ų???????ǷΣ??ξ๰?Ǻ????????±ݱ??̴١?

3.????ȯ?ڿ??½??????????Ұ?

1?????????غ????????α?????ȯ?ڣ?????????angulation?????ظ鼶??????cavernosal fibrosis???Ǵ? Peyronies disease???Ǵ????氭?????Ǽ????̵???????????ȯ?ڣ?????????????????sickle cell anemia?????ٹ߼?????????multiple myeloma???Ǵ¹??????????Դ??̾????????ѹ߱?????ġ?????????????????Ͽ????Ѵ١?

2????????Ÿ?ٶ??ʳ??⣨AUC?????????????ӻ??ڷᣬ??????????Ŭ??????ɷº????????̾? 1?? 1ȸ?????????ѽ????ָ?????ȯ?ڿ??Դ±????????ʴ´١?

3???????????ɺ???ȯ?ڣ?Child-Pugh Class C???????̾??Ǿ????????????ӻ??ڷ??????????̹Ƿ??ǻ??½????ϰ԰????????ͼ?/???輺??benefit/risk?????????Ͽ????ϸ磬?????????ߵ????ǰ?????????ȯ?ڿ??????̾??ǿ뷮?? 10mg???ʰ??ؼ??¾ȵȴ١?

?????ְ??ִ?ȯ?ڵ鿡??Ÿ?ٶ??? 1?? 1ȸ?????뷮???????̿밡?????ڷᰡ?????Ƿ?ó???ϴ°??죬?ǻ??½????ϰ԰????????ͼ?/???輺??benefit/risk?????????Ͽ????Ѵ١?

4?????????ţ?doxazosin???????????ģ?1??????????alpha??1?? blockers?????????ϴ?ȯ?ڿ????̾????????????ϸ??Ϻ?ȯ?ڿ????????????????̳?Ÿ?????ִ١?6.??ȣ?ۿ?????????.??????Ÿ?ٶ??ʰ?????????????alpha blockers?????Ǻ??????????????ʴ´١?

5???????? CYP3A4 ????????ritonavir, saquinavir, ketoconazole, itraconazole, erythromycin?????????ϴ?ȯ?ڿ????̾?????????????Ÿ?ٶ????ǳ??⣨AUC???????????????Ǿ????Ƿ??????Ͽ????Ѵ١?6.??ȣ?ۿ?????????.?̾????????? CYP3A4 ?????????????????Ұ??쿡???̾????????뷮???ְ? 10mg???ʰ??????ʵ????ϸ磬?̾??????? 72?ð????????????Ͽ????¾ȵȴ١?

6???߱???????????????????γ????ѿ??Σ?potential underlying cause???????????????Ƿ????????????????ġ??????Ȯ?????????Ͽ????Ѵ١??̾??̺??Ű溸????ġ??????????????radical non-nerve-sparing prostatectomy????????ȯ?ڿ???ȿ???????????ΰ??˷????????ʴ١?

4.?̻?????

1???ӻ?????????

?ӻ????????پ??????ǿ????ǽõǹǷΣ??Ѿ๰???ӻ????迡???????Ǵ??̻??????߻??????ٸ??๰???????ӻ????迡???ǹ߻??????????????Ҽ????????????ӻ???????Ǵº??????ݿ????????Ҽ????ִ١?

Ÿ?ٶ????????????????νǽ????ӻ????迡?? 9,000???̻??ǳ????????????Ǿ??١? 1?? 1ȸ???????????̾????ӻ????迡?????? 1434, 905, 115???̰????ּ? 6?????? 1?⣬ 2?⵿?????????޾Ҵ١??ʿ??ú????ϴ¿????????ؼ??£? 1300???? 1000???̻??̰?????? 6?????? 1?⵿?????????޾Ҵ١?

?߱????????????ʿ??ú???????

12?ֵ??Ƚǽõ? 8?????ֿ??????????ӻ????迡?????̾???????????ȯ???????տ????? 59????????22-88???????̾? 10 ?Ǵ? 20mg????????ȯ?ڿ????̻??????????????ߴܷ??? 3.1%?ιݸ飬???౺?????? 1.4%???١?

?????????ӻ????迡???????ȹٿ??????ʿ??ú????ϴ¿????????̾????????Ͽ??????????????̻??????̺????Ǿ??٣?ǥ 1????

ǥ 1: ?߱????????????ʿ??ú????????????? 8?????ֿ??????????ӻ????迡?????索ȯ?ڿ????ѽ??????ԣ??̾ࣨ10 ?Ǵ? 20mg????????????ȯ???? 2%?̻???????ǰ??????࿡???ؾ๰?????????????????ϰԺ????Ⱦ๰ġ???????̻?????

?̻?????	????(N=476)	Ÿ?ٶ??? 5mg(N=151)	Ÿ?ٶ??? 10mg(N=394)	Ÿ?ٶ??? 20mg(N=635)
????	5%	11%	11%	15%
??ȭ?ҷ?	1%	4%	8%	10%
????	3%	3%	5%	6%
??????	1%	1%	4%	3%
??????	1%	2%	3%	3%
ȫ??*	1%	2%	3%	3%
?ȴٸ? ????	1%	1%	3%	3%

*ȫ???ǿ????¾ȸ?ȫ????ȫ???????ԡ?

?߱??????????? 1?? 1ȸ????

12 ?Ǵ? 24?ֵ??Ƚǽõ? 3?????????????ӻ????迡?????̾???????????ȯ???????տ????? 58????????21-82???????̾???????????ȯ?ڿ????̻??????????????ߴ????? 4.1%?ιݸ飬??????????????ȯ?ڿ????? 2.8%???١?

12?ֵ??Ƚǽõ??ӻ??????鿡?????????̻????????̺????Ǿ??٣?ǥ 2 ??????

ǥ 2: ?߱????????????̾??? 1?? 1ȸ???????? 12?ֵ????????? 3?????ֿ??????????? 3???ӻ????迡?????索ȯ?ڿ????ѽ??????ԣ??̾? 1?? 1ȸ??2.5 ?Ǵ? 5mg??????????ȯ???? 2%?̻???????ǰ??????࿡???ؾ๰?????????????????ϰԺ????Ⱦ๰ġ???????̻?????

?̻?????	????(N=248)	Ÿ?ٶ??? 2.5mg(N=196)	Ÿ?ٶ??? 5mg(N=304)
????	5%	3%	6%
??ȭ?ҷ?	2%	4%	5%
???εο?	4%	4%	3%
????	1%	3%	3%
???⵵ ????	1%	3%	3%
ȫ??	1%	1%	3%
??????	1%	2%	2%
??ħ	0%	4%	2%
????	0%	1%	2%
??????	0%	2%	2%
?ȴٸ? ????	0%	1%	2%
???? ????	0%	2%	0%
???ĵ? ?????? ??ȯ	0%	2%	1%
????	0%	2%	1%

?????̻??????? 1?????????????ӻ????迡?? 24?ֿ????ĺ????Ȱ??̴٣?ǥ 3 ??????

ǥ 3: ?߱????????????̾??? 1?? 1ȸ???????? 24?ֵ????????? 1?????????????ӻ????迡???̾? 1?? 1ȸ???루2.5 ?Ǵ? 5mg????????????ȯ???? 2%?̻???????ǰ??????࿡???ؾ๰?????????????????ϰԺ????Ⱦ๰ġ???????̻?????

?̻?????	????(N=94)	Ÿ?ٶ??? 2.5mg(N=96)	Ÿ?ٶ??? 5mg(N=97)
???εο?	5%	6%	6%
???忰	2%	3%	5%
????	3%	5%	2%
???⵵ ????	0%	3%	4%
??ȭ?ҷ?	1%	4%	1%
???ĵ??????? ??ȯ	0%	3%	2%
??????	2%	4%	1%
??????	0%	1%	3%
??????	0%	0%	4%

?缺???????????????缺?????????????׹߱?????????????ȯ?ڿ????? 1?? 1ȸ????

12?ֱⰣ?ǣ? 3????????~?????? 3???ӻ????裨???? 2?????缺????????????ȯ?ڣ??????? 1?????缺?????????????׹߱?????????????ȯ?ڣ????????̾???????????ȯ???????տ????? 63????44-93?????????̻??????????????ߴ????? 3.6%?ιݸ飬????????ȯ?ڿ????? 1.6%???١?????̾??????????? 2????ȯ?ڿ????غ?????ġ???ߴ??????????̻????????δµ??룬????????????????̴١????????̻??????̺????Ǿ??٣?ǥ 4 ????????

ǥ4: ?缺???????????????? 1?? 1ȸ???????̾??? 12??ġ???Ⱓ?ǣ? 3????????~?????ӻ????迡?? 1?? 1ȸ?????? 5 mg ġ??ȯ???ǡ?1%?????????ǰ????ຸ?ٳ?????γ?Ÿ???๰ġ???????̻???????2???Ǿ缺?????????????ӻ??? 1???Ǿ缺?????????????׹߱????????????ӻ????ԣ?

?̻?????	????(N=576)	Ÿ?ٶ??? 5mg(N=581)
????	2.3%	4.1%
??ȭ?ҷ?	0.2%	2.4%
????	1.4%	2.4%
???εο?	1.6%	2.1%
????	1.0%	1.4%
?ȴٸ? ????	0.0%	1.4%
??????	0.3%	1.2%
????????	0.5%	1.0%

?߰??????Σ??缺???????????????߱??????׾缺?????????????????ӻ????迡???????????̻???????<1%?????δ????ĵ???????????????????ɣ????䣬?????룬???????ࣨmuscle spasm?????ִ١?

?????Ǵ±???????ǥ 1???? 4?????????Ⱥ?κ????Ǿ??١??̾????ӻ??ฮ???迡?????????Ǵ±????????Ϲ????????????? 12-24?ð??Ŀ??߻??Ͽ??????Ϲ??????? 48?ð??̳????ҽǵǾ??١??̾??????Ͱ??õȿ???/????????Ȯ???????Ϻ??㸮???кΣ??????Ǵµ??㸮??????????Ư¡????Ÿ???磬Ⱦ???????????δ???????ؾ?ȭ?Ǿ??١??Ϲ??????Σ????????????Ǵ??ߵ??????κ????Ǿ???????????ġ?????̼ҽǵǾ????????????ǿ???????????κ????Ǿ??٣????纸???? <5%??????????ġ?ᰡ?ʿ??Ҷ????Ƽ?Ʈ?ƹ̳????Ǵº????׷??̵强?ҿ??????Ϲ???????ȿ????????????ġ?Ḧ???ϴ??????????Ϻο??????浵?Ǹ??༺???????ڵ??Σ??????????????Ǿ??١??????????Σ??ʿ??ÿ????????̾????????Ѹ??????????Ǿ? 0.5%??????/???????ǰ????????????ߴ??Ͽ??١? 1?Ⱓ???????????迡??????????????????ȯ???ǰ??? 5.5%?? 1.3%?????????Ǿ??١????????????ջ??Ǵ½żջ????????????????????˻??????????????????????ѱ????????????Ŵ¾????١??߱????????缺???????????????缺????????????/?߱????????????̾??? 1?? 1ȸ?????????߻?????ǥ 2, 3, 4???????Ͽ??١??̾? 1?? 1ȸ???뿡???ѽ??迡???????????????????̻????????Ϲ??????ΰ????Ǵ??ߵ????̾????????????????????ߴ????? <1%???١?

?̾????????Ѹ????????鿡????????ȭ?Ǻ?µ幰???٣?ȯ???? <0.1%????

?߱????????ʿ??ú?????????????????~?????ӻ??????鿡?????̾??????????? 65???̻???ȯ?ڵ鿡?Լ????簡?????????ϰԺ????Ǿ??١???2.5%??

?????? 1?? 1ȸ?????Ǵ??ʿ??ÿ??????κ??????̾??Ǵ????ӻ????迡?????????߰????Σ??????????̻???????<2%??????Ÿ?????̴١??̷????̻??????????̾????ΰ??????ü???Ȯ???????ʴ١??̸??Ͽ??????ܵȰ????????ϰ????๰?????????ð??ɼ??̾???????Ȯ?????ʾƼ??ǹ̰????»??ʵ??̴١?

???? : ?ٹ??£??ȸ????????ǷΣ??????????ʺ???

???????? : ???????????룬?????У??ɱٰ??????⸳???????У??ɰ????????ǽţ?????

??ȭ???? : ?????ɰ˻???ġ??????????????????ϰ??????ĵ??????????? GGTP ?????????????????ɣ?????????????䣬???ĵ???????ġ??????????????????

?ٰ??ݰ? : ?????룬??????

?Ű??? : ??????????????ϣ??Ҹ??????̻????????????????

?????׺???? : ??????

ȣ?????? : ȣ?????????????????εο?

?Ǻ? : ???????????????

?Ȱ? : ?þ??帲???????̻?ḷ?????ḷ???????ԣ????????????????к???????????Ǯ????

û?? : ???۽?????û?°??ҶǴ»??ǣ??̸?

????ı??? : ?߱????????ڹ????????߱?

2???ؿܽ????Ļ???????

?????̻????????̾??ǽ????Ļ????Ⱓ??Ȯ?εǾ??١??̷??ѹ?????????Ư??ũ???Ǹ????????κ????ڹ??????κ????Ǿ????ǷΣ??׻??๰?????????ΰ??????ü???Ȯ???ϰų????̵??Ǻ???ŷ????????????Ҽ??ִ°????ƴϴ١??̷????̻??????????ߴ뼺??????????????Ѵٸ??????̾????Ǵ??̵????ڵ??Ǻ????????ҷ????????ԵǾ??١?

?????????׳???????~?̾??ǻ??????Ͻ??????ΰ??????ִ°????δ½ɱٰ????????嵹???磬?????ߣ????룬?ɰ????????ɽǺ????ƹ׺????????????ߴ??ѽ????????̻??????̽????ĺ????Ǿ??١??̵?ȯ?ڵ??????δ¾ƴ????????κб????????????????????ڰ??־??١??̷????̻??????ߴ??κ??????????߶Ǵ????Ŀ??߻??Ѱ????κ????Ǿ??????Ϻδ¼????????̣??̾????????Ŀ??߻??Ѱ????κ????Ǿ??١??ٸ??̻??????????̾??????׼??????ļ??ð??????????Ŀ??߻??Ѱ????κ????Ǿ??١??̷????̻??????????̾࣬????????ȯ???Ǳ?????????????ȯ???????????ΰ??????ִ??????̷??????ڵ??Ǻ????????ҵ??????????ִ????Ǵ´ٸ????ڵ??????????ִ??????δ?Ȯ???Ҽ????٣?1.????????????

????~?ε巯?⣬??Ƽ??~???????ı???ǥ?ǹڸ????Ǻο????????Ѱ??ι???

?Ű???~?????룬???۹׹????????ߣ??ϰ?????ü??????????

?Ȱ?~?þ߰??գ????????????⣬???????????⣬???????÷»??????????ѽ÷°????ǿ????̵Ǵº?????????????ýŰ?????Non-arteritic anterior ischemic optic neuropathy [NAION]?????̾????????? PDE5 ???????ǻ??????ñ??????ΰ????Ͽ??????ĵ幰?Ժ????Ǿ??١??̷???ȯ?ڵ??????δ¾ƴ????????κ??̱????????????????ѣ??ݵ????̿??????????¾????? NAION?ǹ??????????غ????????????ڶǴ????????????ڸ????????־??٣??????????Ը???????low cup/ disc ratio, crowded disc???? 50???̻?索?????????У????????ȯ????????????????????5.?Ϲ???????????????

û?????????̾????????? PDE5 ???????ǻ??????ñ??????ο????????ִ°????ΰ??۽?????û?????ǶǴ°????????ʰ??????Ǿ??١??Ϻ????ʿ?????û???̻????????߿??ѿ??????Ҽ??ִ??????????¹ױ?Ÿ???ڵ??̺????Ǿ??١????????ʿ????????????????????????????????̾??١??̷??Ժ??????̻????????̾??ǻ??????????????ΰ??????ִ?????ȯ????û?????ǿ????ѱ??????????ڿͰ??????ִ??????̷??????ڵ??Ǻ????????ҿ????Ѱ????????ٸ????ڿ????Ѱ????????δ?Ȯ???Ҽ????٣?5.?Ϲ???????????????

????ı??????ӹ߱?????1.????????????

?鿪??????????

3???̾? 1?? 1ȸ?????ý??????̻??????????????ƣ?Primarily sinus bradycardia???????౺???پణ???Թ????Ǿ??١????κ??ǽ??????̻????̻????????????Ͽ??١?

4????????????????????

??Ÿ?ٶ??? 5mg ???????ǽ?????????????

?ܱ??????????ɻ縦???Ͽ? 4?⵿?? 613???ǹ߱?????ȯ?ڸ????????νǽ??ѽ??????????????????ػ??ʹ??????????????ΰ????迡???????? 4.73%??29??/613???? 37?ǣ??γ?Ÿ?????磬?????̾??????ΰ????踦?????Ҽ????¾๰???ع??????????? 3.75%??23??/613???? 31?ǣ??̾??١?

?๰???ع????????? 1.14%??7??/613??????7?ǡ?,?????? 0.82%??5??/613??????5?ǡ?,ȫ?? 0.65%??4??/613??????4?ǡ?,?ȸ?ȫ?? 0.49%??3??/613??????3?ǡ?,????????????? 0.33%??2??/613??????2?ǡ?,?̻?????ð????֣??ɰ?????????ȭ?ҷ????ȸ??????? 0.16%??1??/613??????1?ǡ??????????Ǿ??١?

?ߴ??Ѿ๰???ع??????????١?

???????????Ѿ๰???ع??????ð????? 0.16%??1??/613??????1?ǡ????κ????Ǿ??١?

??Ÿ?ٶ??? 10mg, 20mg ???????ǽ?????????????

?ܱ??????????ɻ縦???Ͽ? 6?⵿?? 10,500????ȯ?ڸ????????νǽ??ѽ??????????????????ػ??ʹ??????????????ΰ????迡???????? 3.94%??414??/10,500???? 517?ǣ??γ?Ÿ?????磬?????̾??????ΰ????踦?????Ҽ????¾๰???ع??????????? 3.47%??364??/10,500???? 461?ǣ??̾??١?

?๰???ع????????룬?ȸ?ȫ?????? 1.30%??136??/10,500???? 136?ǣ??ΰ??帹?????磬??ȭ?ҷ? 0.33%??35??/10,500???? 35?ǣ????????? 0.19%??20??/10,500???? 21?ǣ????????? 0.12%??13??/10,500???? 13?ǣ??????????? 0.11%??12??/10,500???? 12?ǣ??????? 0.07%??7??/10,500???? 7?ǣ??????ӹ߱??? 0.06%??6??/10,500???? 6?ǣ??????׿??????????? 0.06%??6??/10,500???? 6?ǣ??????? 0.05%??5??/10,500???? 5?ǣ????ɰ????? 0.04%??4??/10,500???? 5?ǣ??????????׿???????Ƽ??SGPT???????? 0.04%??4??/10,500???? 4?ǣ????????з°??????䣬????????Į???λ?????ȿ?????????Ƿΰ? 0.03%??3??/10,500???? 3?ǣ????????????䵵????????????????????????????????????????????ȯ???????????????????????????ǰ????????Ҿȣ????????֣??????Ұ??Ұ? 0.02%??2??/10,500???? 2?ǣ????????? 0.01%??1??/10,500???? 2?ǣ??????룬?????룬????ȣ????????????????Ǯ?α⣬?ḷ???????????????????ΰ??ã??????????????????????֣??ٱ????ı?????????ȫ?ݣ????????????????֣?ȫ?????????????ɱٰ????????Ϳ︲???????????ڸ?????ũ????Ƽ???????????????????????????????κ??裬???룬?˷??????????????????????????????Ƽ??SGOT?????????????????????? 0.01%??1??/10,500???? 1?ǣ??Ǽ??????????Ǿ??١?

?ߴ??Ѿ๰???ع??????ȸ?ȫ?? 0.02%??2??/10,500???? 2?ǣ??̾??١?

???????????Ѿ๰???ع??????????? 0.31%??33??/10,500???? 37?ǣ????Σ????׿??????????? 0.06%??6??/10,500???? 6?ǣ?????Į???λ?????ȿ?????? 0.03%??3??/10,500???? 3?ǣ??????????????????????????Ҿȣ??䵵?????????????????????Ұ??ң??????ǰ??????̰? 0.02%??2??/10,500???? 2?ǣ???????ȣ?????ḷ?????????????????????????????????????????ٱ????ı????????????????֣????????????֣??ڸ?????ũ????Ƽ????????????????????????ȫ???̰? 0.01%??1??/10,500???? 1?ǣ??????????Ǿ??١?

5???????ڹ??????ۿ뺸???????????ۿ??̺????ȴٸ??Ǿ?ǰ?????߻??Ѻ??ۿ????????Ͽ????????????????ϰԹ߻??????ػ????߿??????????????ػ??ʴ´????????̳?Ÿ???١??ٸ????̾??????ΰ???????Ȯ?ε????ʾҴ١?

ȿ????????medicine ineffective??

???? : ????

?ٰ??ݰ? : ????????

5.?Ϲ???????

1??ȯ???Ǵ??????ʶǴ¾??ʴ????????۽????÷»????̹߻??ϴ°??죬?ǻ????̾????????? phosphodiesterase type 5??PDE5?????????ǻ??????????Ұ???ȯ?ڿ??Աǰ??ϰ????????????Ǹ????￩???Ѵ١??̷????????????????ν÷»??????????ѽ÷°????ǿ????̵ɼ??ִ£??幰?Գ?Ÿ?????????κ?????????????ýŰ?????Non-arteritic anterior ischemic optic neuropathy, NAION????¡?İ??ɼ??????磬?̴½????????翡???幰?Ժ????Ǿ??? PDE5 ?????????????????????λ????????ִ°????γ?Ÿ???١???ǥ?ȹ??忡?????飬??????????????ýŰ????ǿ????߻????? 50???̻??ǳ??????? 100,000???? 2.5-11.8???̴١?

??????~???????????????? NAION ????????????5 ?ݰ????̳??? PED5 ???????迭???????Ѱ????? NAION ?????̱׺??پռ??Ⱓ?? PDE5 ?????????????Ѱ????ͺ????Ͽ???Ǿ??١????????? NAION ?????̾? 2???????ϴ°????????õǾ????磬????????ġ?? 2.15 ??95% CI 1.06, 4.34?????١??????ѽ??迡?????ϰ??Ȱ??????????Ǿ????磬????????ġ?? 2.27 ??95% CI 0.99, 5.20???̾??١??̵????迡???¡??????ȡ??ýŰ????????????Ͱ??? NAION?Ǳ?Ÿ?????????? NAION ?߻????⿩???????ִ١????????ǵ幮?????Ǵ°??????????? PDE5 ???????????? NAION?ǰ??ü??? PDE5 ???????????? NAION ???????ΰ????踦?޹?ħ?????¾ʴ´٣?4.?̻?????????????

?ǻ??±????Ǻ?????????????ýŰ??????????ڰ??ִ?ȯ?ڵ??? PDE5 ?????????????????????ѿ????????????ִ??????θ??????ؾ??Ѵ١??̹̺?????????????ýŰ????????????????ִ»????ǰ??죬??????????????ýŰ??????????????̴????١???????̷?ȯ?ڵ鿡???̾????????? PDE5 ?????????????ϴ°??????Ǹ????￩???ϸ磬?????Ǵ????ͼ???????????ȸ?ϴ°??쿡???????ؾ??Ѵ٣?4.?̻???????????????

2???̾????????̻??Ǵ?Ȱ??????ȭ???˾?ȯ?ڿ????????Ѱ????̾??١??????̾??̰ǰ????????ڿ??Լ????????ð?????????Ű???ʴ°????γ?Ÿ?????????????̻??Ǵ?Ȱ??????ȭ???˾?ȯ?ڿ??Դ????ͼ?/???輺?????????Ľ??????????Ѵ١?

3???̾??????ڿ??????ΰ?????????Ȯ???ۿ????????Ƿκ????????????а????ۿ????????ɼ??ִ١??ǻ??¸??????Ǿ??ڿð??̾??Ǻ????????ýɹڼ??????????а??ң??????????????????⸳?????Ĺ??????̳?Ÿ??????????ȯ?ڿ??Ծ˷??־????Ѵ١?

4?????۽???û?°????Ǵ³?û???̸??????????̵??ݵɼ????????̹߻??ϴ°??죬?ǻ????̾????????? PDE5 ???????ǻ??????????Ұ???ȯ?ڿ??Աǰ??ϰ????????????????Ǹ????￩???Ѵ٣????̻????????ס??????????硯????????

5??Ÿ?ٶ??? 5mg 1?? 1ȸ?????? 2?? 6?????̻????ӻ??????????????٣?Ÿ?ٶ??? 5mg ???????????ԣ???

?þ˸??? ???? | ?þ˸??? ???? | ?þ˸??? ?Ǹ? ????????Ʈ

?þ˸??? ???԰? ?ùٸ? ??????: ???????? ????