48?ð? ?? ?ڷγ?19 ??????Ű?? ?????? '?̹? ??ƾ'?̶??
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?̹? ??ƾ, ?????? ??????Ű?? ???????? ?پ??? ?????? ???? ġ?ῡ ????
?̹? ??ƾ, SARS-CoV-2 ???̷????? 48?ð? ?̳? ??????Ű?? ?????? ??Ÿ??
???????? ?̹? ??ƾ(ivermectin)?? ?ֱ? ???? ???? ???迡?? ?ڷγ?19?? 48?ð? ?̳? ??????Ű?? ?????? ??Ÿ????.
?? ?̹? ??ƾ?? ?ڷγ?19?? ????Ű?? SARS-CoV-2 ???̷????? ?????ִ? ????ü ?? '?κ?Ʈ??(?????? ??, in vitro)' ȯ?濡?? 48?ð? ?̳? ???????״?.
???????? ?̱???ǰ?Ǿ౹(FDA) ?㰡?? ???? ?̹? ??ƾ?? ???? ???? ???迡?? ???̷????? 5000?? ???̴? ?????? ??Ÿ???鼭 ???????? ???? ???ټ??? ???? ?????? ???? ?̹? ??ƾ?? ???߰?(repurposing) ?ʿ伺?? ?????ߴ?.
?????? Ȯ???ϴ? ?ڷγ?19 ??????, ???? ġ?????? ????
?? ???? ?ڷγ?19 Ȯ???ڰ? 127?????? ?Ѱ? ???? Ȯ???ڵ? 1?????? ?ѱ??鼭 ?????????? ?ڷγ?19 ġ?????? ?ĺ? ?? ?????Ϸ??? ?? ?????? ?????̰? ?ִ?.
Ư?? ????? ġ???? ???̵??Ͻ?Ŭ?η???, HIV ġ???? ???dz?????+???䳪????(??ǰ?? Į??Ʈ??), ?װ??????? ?λ縣ź(??ǰ?? ????)???? ?????? ?ڷγ?19 ġ?????? ?ΰ??????? ???? ?ڷγ?19?? ??????Ű?? Ȯ???? ġ?????? ?????? ?ʾҴ?.
?̿? ȣ?? ?ξ???????????(Royal Melbourne Hospital)?? ???丮?? ?????? ??????(Victorian Infectious Diseases Reference Laboratory) Leon Caly ???????? ???? 3?? Antiviral Research?? ???? ?????? ??ǥ?ϸ鼭 ?ƹ???ƾ?? ?????? ?ڷγ?19 ġ?????? ?? ?ִٰ? ??????.
Caly ?????? "?̹? ??ƾ?? ?κ?Ʈ?? ȯ?濡?? ???????? ???̷??? Ȱ???? ???? ?־? FDA?? ???????? ?????ߴ?"?? "?̹? ??ƾ?? ?????? 2?ð? ?̳? Vero-hSLAM ?????? ?????ϸ? 48?ð? ?̳? RNA ???̷????? ?? 5000?? ???? ?? ?־? ?? ??? ?ΰ????? ȿ?? ?ִ??? ?????? ?ʿ䰡 ?ִ?"?? ??????.
?̹? ??ƾ?̶??
?̹? ??ƾ?? ?پ??? ?????? ?????? ġ???ϴ? ?? ?????ȴ?. FDA ?㰡 ??Ȳ?? ?????? ?̹???ƾ?? ?Ӹ???, ??(scabies), ???;???(river blindness), ?м?????, ??????, ȸ???? ?? ???????????? ġ??????.
?̹? ??ƾ?? ???????? ?????? ??????Ű?? ?ƹ???ƾ(avermectin) ? ?迭?? ???Ѵ?.
?̹? ??ƾ?? 1975? ?Ϻ? ??Ÿ?????? Satoshi Omura ?????? ???Ϸ??? ?????? ??ũ??ǻƽ????ġ????(Merck Institute for Therapeutic Research) William C. Campbell ?????? ?????ߴ?.
???? 2015?? ?ƹ???ƾ?? ???????? ?߰??? ???θ? ?뺧 ???????л? ?????ڷ? ?̸??? ?÷ȴ?.
Omura ?????? ?̹? ??ƾ?? Streptomyces avermitilis ?????ƿ??? ?ĺ??????? Campbell ?????? Omura?? ?ĺ??? ???繰?κ??? ?̹? ??ƾ?? ?????ߴ?. ?̴? ?? ???? ?? ?????ϰ? ?????? ???? ?̹???ƾ?? ?߰????? ?̾?????.
?̹? ??ƾ?? ?????? ???? ?????? ??????(endectocide)??, ???? ?? ǥ?鿡 ?????ϴ? ?????濡 ?ۿ??? ?? ?ִ? ????????. ?̹???ƾ?? ???? ??????? ?? 0.12 ???? ġ?????? ?? ?????? ?̱??????? ?? 50???? ???Ѵ?.
?̹? ??ƾ ? ?ۿ? ?????? ?????????
?̹? ??ƾ?? 1981? ?Ƿ? ?Ǿ?ǰ???? ?????ǰ? ?????? ???躸?DZⱸ(WHO)?? ?ʼ? ?Ǿ?ǰ ????(List of Essential Medicines)?? ?߰??ߴ?. ??? ó???? ???????? ?????ƴ?. ??? ???????? ????, ???? ȸ??, ???ĸ?, ??(lice) ?? ?????⸦ ġ???ϴ? ?? ?????????? ?ֿϰ߰? ?ҿ? ???? ?????ȴ?.
???? ?ΰ? ?Ȱ? ?̸? ġ???ϴ? ?? ???? ?????????? ȸ??(roundworm) ?? ????(whipworm)?? ????Ű?? ???????? ?????? ġ?????? ?????ȴ?.
?̹? ??ƾ?? ???????? ??????Ų ?????? ??????Ų??. ??? Ư?? ???????? ?Ű??迡?? ?Ű? ???? ?????? ???????? ?ʰ? ?????ǵ??? ?????? ???????? ?????ϸ? ???????? ???ĵ? ???߰ų? ???? ?˷?????.
???? ?Ű? ???? ?????? ?ۿ??ϳ?, ???? ?庮?? ?̹???ƾ?? ???? ?????ϴ? ???? ???´?.
???????? ġ?????? ?̹? ??ƾ???
?̹? ??ƾ?? ġ?????߹??̷???, ?????, ???? ?? ?Ͽ? ?????? ġ?????? ?? ?ִٰ? ?????? ?? ?ִ?.
?ɶ??? ????Ű?? ?? ???? ????(University of Bonn) ??Į???? ???????? ?̹???ƾ?? ġ?????߹??̷???(chikungunya virus)?? ȿ?????? ?? ?ִٰ? ??ǥ??????, ?̱? ?ݷζ????ָ??? Brian D Foy ???????? ?̹???ƾ?? 5?? ???? ?Ҿƿ? ????? ???? ?????ٰ? ?߰??ߴ?.
ij???? ?긮Ƽ???÷????ƴ? ???????? ?? ?̹? ??ƾ?? ?????? ????Ű?? ?????Ƹ? ȿ???????? ???̴? ???? ?߰??ߴ?. ?Ӹ? ?ƴ϶? ?Ϻ? ????ī?? ???????? ?̹? ??ƾ?? ???? ?? ?? ???Ǽ????ҾϿ? ?????? ?Բ? ?????Ǹ? ġ?? ȿ???? ?????Ѵٰ? ??ǥ?ߴ?.
?ڷγ?19?? ?????? ?̹? ??ƾ???
?ڷγ?19?? SARS-CoV-2 ???̷????? ???? ?Ͼ?? ??ȣ???????ı??? SARS-CoV?? ?????? ?????? ?˷?????.
?????? SARS-CoV ?ܹ??????? IMP??/??1?? ???? ?????? ?????? ?????´?. IMP??/??1?? SARS-CoV ??Ŭ????ĸ?õ? ?ܹ????? ??ȣ???????? ?ټ?????????(nucleocytoplasmic shutting)?? ?????? ?? ?? ?ִٴ? ???̴?. ?̴? ???̷??? ?????? ?? ?ӿ??? ?????ϴ? ?Ϳ? ?????? ??ĥ ?? ?ִٴ? ???? ?û??Ѵ?.
?????? ?̹? ??ƾ?? ?ټ??۾???Ȱ??(nuclear transport inhibitory activity) ȿ???? SARS-CoV-2?? ȿ?????? ?? ?ִٰ? Caly ???????? ?????ߴ?. ?̹? ??ƾ?? ?????? ???? ?ܹ????? ?ټ???(nuclear import) ?? HIV-1 ?????? ?????ϴ? ?????? Ȯ?εƴ?.
???????? ?ڷγ?19 ?????????? ?????? Australia/VIC01/2020 ?????ָ? vERO/Hslam ?????? ?????ǿ??? ???????״?. ???? ?̹? ??ƾ?? ?????ߴ?.
?? ????, ?̹? ??ƾ?? ?????? ?????? ??û?? 24?ð? ?̳? RNA ???̷????? 93% ?????ƴ?. ?? ?????????? ???̷????? 99.8% ???? ?????? ??Ÿ????.
48?ð??? ?????? ???????? ???? ?̹? ??ƾ ġ???? RNA ???̷????? 5000?? ?پ???. 72?ð? ?? ???̷????? ?? ?̻? ???????? ?ʾҴ?. ?????? ?????? ???? ?????? ?????ƴ?.
???????? "?ٸ? RNA ???̷????? ?????ϰ? IMP??/??1 ?Ű??? ???? ?ټ???(nuclear import)?Ǵ? ???̷??? ?ܹ????? ?????????ν? ?̹???ƾ?? ȿ?????? ?? ?ִٴ? ?????? ??????"?? ???ߴ?.
ġ???? ?? ???ۿ????
?̹? ??ƾ?? ó?? ?????? ???????? ?????ϰų? ?Ǻο? ?ٸ? ?? ?ִ?. ?뷮?? ġ???ϴ? ?????? ???? ?????? ??? ???ĸ??? ???? ?????????? ???? ?????ϸ? ?????? ???? ?̻??????? ?Ͼ ?? ?ִ?.
???? ???? ???ۿ??? ??????, ????????, ?? ??????, ????????, ?????? ????????, ???? ???? ?ִ?.
???? ??ǰ?Ǿ?ǰ????ó?? ?̹? ??ƾ?? ???????? ???????? ?ʾ? "?Ϲ??????? ???????? ???? ???????? ??? ġ?????? ???ߵǷ??? ?ӻ????? ?? ?߰? ?????? ?ʿ??ϴ?"?? ??????.
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