ATA :: Advances Test of Attention 

Brain Medic


[???Ƹ?Ʈ] ??Ʈ?? 1+1?ڽ?(20pack) 0
 
  작성자: AD  2025-03-14 10:44
조회 : 25  
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??Ʈ?? 1+1?ڽ?(20pack)
ȿ?? ?? ȿ??
?߱??????? ġ??
?? ???? ȿ?????̷???, ?????ڱ?(sexual stimulation)?? ?ʿ??? ?Ѵ?. ?? ???? ?????? ???? ?????? ?? ?????????? ???? ?ʴ´?.
 
???? ?? ?뷮
?汸 ??????. 
???? ?????????? ????
?? ???? ???? ?뷮?? 20mg?̸?, ?????Ǵ? ?? ???? ???? ?Ļ翡 ???????? ?????Ѵ?.  
Ÿ?ٶ??? (tadalafil) 10mg?? ?????? ȿ???? ??Ÿ???? ?ʴ? ȯ?ڵ鿡?Դ? 20 mg?? ?õ??Ͽ??? ????.  ?? ???? ??? ?? ???? 30 ?? ??????  ?????? ?? ?ִ?.
?ִ? ???? ???? ??? 1?? 1ȸ?̸?, ?? ???? ???? ???忡?? ???? ???Ŀ? ?ٷ? ?? ???? ????, ?쿩?? ?? ???? ?????Ѵ?.
?????? ???? ???? ?Ŀ? ???? ???Ⱓ ???????? Ȯ?????? ?ʾҰ?, ???? ?? ???? ȿ???? ???? ?Ϸ? ?̻? ???ӵDZ? ?????? ?? ?????? ?????????? ???? ?????ϴ? ???? ???ϰ? ???????? ?ʴ´?. [1.???? ?? ?? 11.1) ???????? Ư?? ?? ????]  
???? ?????????? ????
???? ȯ?ڿ??? ?뷮 ???? (dosage adjustments)?? ?ʿ??? ???? ?ʴ´?.
?ű??? ???ְ? ?ִ? ?????????? ????
???? ???? ?ߵ?? ?????ְ? ?ִ? ȯ?ڿ??? ?뷮?????? ?ʿ??? ???? ?ʴ´?. ???? ?????? ȯ?ڿ??? ?ִ? ?????뷮?? 10mg?̴?. [11.2) ?ൿ???? Ư?? ?? ????].
?? ???? ???ְ? ?ִ? ?????????? ????
???? ?뷮?? 10mg?̸?, ?????Ǵ? ?? ???? ???? ?Ļ翡 ???????? ?????Ѵ?.  ???? ?????ɺ??? ȯ??(Child-Pugh Class C)???? ?? ???? ???????? ???? ?ӻ??ڷ???  ???????̹Ƿ? ó???ϴ? ????, ?ǻ??? ?????ϰ? ?????? ????/????(benefit/risk) ?? ?????Ͽ??? ?Ѵ?. ?? ???? (hepatic impairment) ȯ?ڵ鿡?? 10mg ???? ???뷮?? ?????? ?ڷᰡ  ????. [3.???? ȯ?ڿ??? ?????? ?????? ?? ?? ?? 11.2) ?ൿ???? Ư?? ?? ????].
?索???? ?ִ? ?????????? ????
?索?? ȯ?ڿ??? ?뷮 ?????? ?ʿ??? ???? ?ʴ´?.
?Ҿ? ?? û?ҳ⿡???? ????
?? ???? 18?? ?̸??? ???????? ?????ؼ??? ?? ?ȴ?.
 
????????
- ?????????? ?ɰ??? ???ۿ??? ??Ÿ?? ?? ?????Ƿ? ?ݵ??? ?????? ???????뷮?? ?????ּ???.

- ?????ʱ⳪ ???? ?? ?ȸ?ȫ??, ???? ???? ?????? ?Ͻ??????? ??Ÿ?? ?? ?־???.
- ???о??? ???? ???? ȯ?ڴ? ?????????? ?̸? ?˸?????.
- ???????? ??ȯ?? ?ִ? ???? ?????????? ?̸? ?˸?????.
- ?߱??????? 4?ð? ?̻? ???ӵǸ? ?ǻ翡?? ?˸?????.
 
???????? ???ǻ???
[?㰡???׺???(??????), ?Ǿ?ǰ??????-9182, 2021.01.05]
1. ????
 1)?? ?????? ġ?????? ???̳? ġ?? ?? ?? ġ?? ?? ???? ?????? ???꿰 ???? ?Ǵ? NO ?????? (??Ʈ?α۸?????, ???????ƹ?, ?̼ҼҸ????????꿰) ?? ?????ϴ? ???? ???а????ۿ??? ?????Ǿ? ?????ϰ? ?????? ?????? ?? ?????Ƿ? ?ǻ??? ?? ???? ó???ϱ? ???? ȯ?ڰ? ???꿰 ???? ?? NO ???????? ???????? ?ʾҴ??? ?????? Ȯ???Ͽ??? ?ϸ? ?? ?? ???? ?? ?? ???? ?? ???꿰 ???? ?? NO ???????? ???????? ?ʵ??? ???ǽ?Ų??.
 2)?ܱ??? ???? ???? ?? ?̻????? ?????͸? ???? ???????? ?̻????????? ???? ???? ???? ?̻??????? ?????Ǿ????Ƿ? ???????? ???? ?????? ?????? Ȯ???Ͽ??? ?Ѵ?.
 3)???????? ??ȯ?? ???? ȯ?ڵ??? ???????? ?? ???? ???忡 ???? ?????? ???ɼ??? ?????ϹǷ? ?? ???? ?????? ?߱??????? ġ?????? ???????? ???¸? ?????Ͽ? ???????? ???????? ?ʴ? ȯ?ڿ??Դ? ???????? ?ʵ??? ?Ѵ?. 
 4)?? ???? ?ǰ??? ?????ڿ??? ???? ?ڼ? ?????? ?Ͻ????? ???Ҹ? ?ʷ??ϴ? ???? ????Ȯ???? Ư?? (???? ?ִ밨??: 8.4/5.5 mmHg) ?? ??????. ?̴? ?????? ȯ?ڿ????? ?߿????? ???? ?? ?????? ?? ???? ?????ϱ? ???? ?ǻ硤?????? ???????? ??????ȯ?? ???? ȯ?ڰ? Ư?? ???????? ?? ???? ?̷??? ????Ȯ??ȿ???? ???? ?̻??????? ???? ???ɼ??? ?????? ?????Ͽ??? ?Ѵ?. 
 5)???? ȯ?ڿ? ???? ?? ???? ??ȿ???̳? ???????? ???Ͽ? Ȯ???? ?ӻ??ڷ??? ????. ?? ???? ?????? ?????ؾ? ?Ѵ?
- ???? 6???? ?̳? ?????? ?????ϴ? ???????? ?־??? ȯ??
- ?ɺ??? ȯ?? ?Ǵ? ?Ҿ????? ???????? ?????ϴ? ???????ȯ??
- ??????ȯ?? (90/50 ?̸?) ?Ǵ? ??????ȯ?? (170/100 ?ʰ?)
- ???Ҽ? ??????ȯ??
 6)4?ð? ?̻??? ???ӵ? ?߱? ?? ???ӹ߱??? (6?ð? ?̻??? ?????? ?????? ?߱?) ?? ???? ?Ŀ? ?幰?? ?????Ǿ???. 4?ð? ?̻? ?߱Ⱑ ???ӵ? ???? ???? ?ǻ??? ???? ?? ?????? ?޾ƾ? ?Ѵ?. ???ӹ߱????? ???ٷ? ġ?????? ?????? ???? ?????ջ? ?? ?߱????? ???? ?????? ?߱??? ?? ?ִ?.
 7)?½ɽ????????? (??: ?뵿?? ?????? ?? Ư?ߺ??Ĵ뵿???? ?Ϻ? ??????)?? ?ְų? ?????ڵ??????ɷ??? ?ɰ??ϰ? ?ջ??? ȯ?ڴ? PDE5 ???????? ?????? ????Ȯ?????? ?ۿ뿡 ?ΰ??? ?? ?ִ?.
 8)?ܹ?????ȿ?? ???????? ???䳪?????? ?????? ?ǵ??????? ???? ??? ?? 11?? ???? ??Ű?Ƿ? ???䳪??? ?????ϴ? ȯ?ڿ??? ?? ???? ?????ϴ? ???? ?????Ͽ??? ?Ѵ?. ???????? ?ǵ????ʿ? ?????? ȯ?ڷκ??? ???? ?ڷ??? ?????Ǿ? ?ִ?. ???????? ?ǵ????ʿ? ?????? ???? ?ð??̻??? ??? ???? ???? ??Ÿ????. ???뷮?? ?ǵ????? (200-800 mg) ?? ?????? ?ǰ??? ?????? ?? ?Ϻο??Լ? ???? ????, ?ǽ?, ???ӹ߱Ⱑ ?????Ǿ???. ???䳪??? ?????ϴ? ȯ?ڿ????? ?̻????? ???? ???ɼ??? ???ҽ?Ű?? ???ؼ??? ?ǵ??????? ?뷮?? ?ٿ??? ???? ?ϴ? ???? ?????ȴ?.
 9) ?? ?࿡ ?????Ǿ? ?ִ? ?ΰ??????? ?ƽ???Ž?? ü?????? ???صǾ? ???Ҿ˶??????? ?????ǹǷ?, ???Ҿ˶????? ???븦 ?????? ?ʿ䰡 ?ִ? ????????ȯ?? ???????洢?? ȯ?ڿ??? ???????? ?? ?? (?ƽ???Ž ???????? ????)
  * 1?? ???뷮????
    ?ƽ???Ž ?Է??? WHO???差(40mg/kg/1??)???Ϸ? ????(???????? ?ּҷ? ????)?? ??. 
    60kg ???? : 1?? ?ִ뺹?뷮 2.4g
2. ???? ȯ?ڿ??? ???????? ?? ??
1) ?? ?? ?Ǵ? ?? ???? ???????п? ???ι??? ȯ??
2) ??? ?????? ???? ???꿰 ???? (??Ʈ?α۸?????, ?̼ҼҸ????????꿰, ???????ƹ?, ??Ʈ???????õ峪Ʈ??) ???? ?????????? Ȥ?? ?????????? ?????ϴ? ȯ??
: ?? ???? ?????? ?Ŀ? ?ʿ信 ???? ???꿰 ?????? ?????ؾ? ?? ????, ???? ?????ϴ? ???? ?????????? ???ؼ??? ?˷??? ???? ?ʴ?. ?ǰ??? ???? ?????ڿ? ???? ?汸?? 100 mg ???? ?????? ?????? ?๰???? ???????Ͽ? ?ٰ????? ??, ???? ?? 24?ð??? ???? ?????????? ?? ???? ???? ??? ?? 2 ng/mL?̴? (?ְ? ???? ??? ?? 440 ng/mL). 
?????? ???? ȯ?ڵ? - ??, 65?? ?̻??? ??????, ?????? ȯ??(??, ???溯), ?????? ?ź??? ȯ??(??, ũ????Ƽ??û?????? 30 mL/min ????) ?׸??? CYP3A4?? ???? ?????? ??????(??, ????Ʈ?θ??̽?)?? ?????ϴ? ???? - ???? ???? ?? 24?ð??? ???? ?????????? ?? ???? ???? ??? ?ǰ??? ?????ڿ??? ?????? ?ͺ??? 3-8?? ?? ???? ?????? ?????Ǿ???. ???? ?? 24?ð??? ???? ?????????? ?ǵ??????? ???? ??? ?ְ? ???? ??? ???? ?ξ? ??????, ?? ???????? ???꿰 ?๰?? ?????ϴ? ???? ?????? ???? ???ؼ??? ?˷??? ???? ?ʴ?.
3) ???????? ??ȯ ???? ?????Ͽ? ????Ȱ?? ???????? ?ʴ? ȯ??: ?Ҿ????? ?????? ?Ǵ? ???? ?ɺ????? ???? ???? ?????? ??ȯ??
4) ???? ?????? ȯ??
5) ?????? (???? 90/50 mmHg ?̸?) ?Ǵ? ???????? ?ʴ? ?????? ȯ?? (?޽Ľ? ?????? ???? 170 mmHg ?ʰ?, ?޽Ľ? ?̿ϱ? ???? 100 mmHg ?ʰ?)
6) ?ֱ? 6???? ?̳? ?????? ?????ϴ? ??????, ??????, ?????? ?Ǵ? ?ɱٰ????? ?־??? ȯ??
7) ???Ҽ? ?????? ȯ??(?Ҽ??? ???Ҽ? ?????? ȯ?ڴ? ?????? PDE?? ?????? ??ȯ?? ????)
8) ?ٸ? ?߱????? ġ?????? ???????? ȯ?? (?? ???? ?ٸ? ?߱????? ġ???????? ?????????? ???? ????????ȿ???? ?????? ?? ????)
9) ?????? PDE5 ?????? ???? ???ο? ????????, ??????????????ýŰ??? (Non-arteritic anterior ischemic optic neuropathy, NAION) ???? ???? ???? ???? ?÷??? ?սǵ? ȯ??
10) 18?? ?????? ?Ҿ?, ????
11) ?ƹ̿??ٷп??꿰(?汸??)?? ???????? ȯ??
12) ?????ñ??? ?? guanylate cyclase ?ڱ??? ???? ȯ?? (?????????? ???а??Ͽ? ???? ?????? ???????? ????ų ?? ????)
3. ???? ȯ?ڿ??? ?????? ?????? ??
1)?غ??????? ?????? ???? ȯ?? (??????, ?????ظ?ü ???????????? ?Ǵ? ???̷δϺ?(Peyronie's disease))
2)???ӹ߱????? ?????? ???? ?? ?ִ? ?????? ȯ?? (????????????, ?ٹ߼? ??????, ??????)
3)?????̻? ?Ǵ? Ȱ???? ??ȭ???˾? ȯ?? (??Ʈ???????õ峪Ʈ???? ?????? ???????? ?ۿ??? ??????Ű?? ?????? ???δ?. ?????̻? ?Ǵ? Ȱ???? ??ȭ???˾? ȯ?ڿ? ???? ???????? Ȯ???Ǿ? ???? ?ʴ?.)
4)?????? (?????ڿ??? ???߳?? ?????ϴ? ???? ?????Ǿ????Ƿ? ??ȸ ?? ???? ???뷮 (25 mg) ???? ?????ؾ? ?Ѵ?.)
5)?????ź???ȯ?? (ũ????Ƽ??û???? 30 mL/min ????) (??????? ?????ϴ? ???? ?????Ǿ????Ƿ? ??ȸ ?뷮?? ???뷮(25 mg) ???? ?????ؾ? ?Ѵ?.)
6)?????? ȯ??(??????? ?????ϴ? ???? ?????Ǿ????Ƿ? ??ȸ ?뷮?? ???뷮 (25 mg) ???? ?????ؾ? ?Ѵ?.)
7)CYP3A4 ???????? ???????? ȯ?? (??????? ?????ϴ? ???? ?????Ǿ????Ƿ? ??ȸ ?뷮?? ???뷮  (25 mg) ???? ?????ؾ? ?Ѵ?.)
8)ī???丮Ƽ?带 ???????? ȯ??
9)?索???? ?????? ȯ?? (?? ???? ?索???? ?????? ȯ?ڿ? ???? ???????? ???????? ?ʾ????Ƿ? ???ͼ?.???ؼ? ??? ?????ϰ? ?ǽ??? ?? ?????ؾ? ?Ѵ?.)
10)?ִ? ??õ ?뷮???? 100 mg?? ?ʿ??? ȯ???? ???? ?̻????? ???????? ?????? ?? ?ִ?.
11)???Ⱓ ?????? ???? ???? ???????? ??ȯ ȯ??, ??????, ??????, ?ɱٰ????? ?????? ?ִ? ȯ?ڿ??? ?????? ???? ???????? ??ȯ?? ???? ???? ?????? Ȯ???Ͽ??? ?Ѵ?.  ?? ???? ?????? ?????ϱ? ???? ?׵??? ???????? ???¿? ???? ?????ϰ? ??Ǿ??? ?Ѵ?.
???????? ???? ???ڸ? ?????? ?ִ? ȯ?ڿ? ?־ ???????? ?????????? ???忡 ???? ?????? ?? ?? ?ִ?. ???????? ?????? ?? ?̿? ???õ? ????(??, ??????, ??????, ????)?? ?????? ???? ?ִ? ȯ?ڴ? ?? ?̻??? ?????? ?ﰡ?? ?? ?????? ???? ?ǻ????????? ?????Ͽ??? ?Ѵ?. 
12)?ٹ߼? ???? ?????? (Ư?߼? ?⸳?????? ???? (Shy-Drager syndrome) ??) ?? ?ִ? ȯ?? (?? ???? ????Ȯ?? ?ۿ??? ȯ???? ???? ??ȯ?? ???? ?߱??? ?????? ???¸? ??ȭ??ų ?? ?ִ?.)
4. ?̻?????
?̻??????? ?Ϲ??????? ?Ͻ????̰? ?? ?????? ???????? ?ߵ????. ?????뷮 ???????? ?Ϻ? ?̻??????? ?뷮?? ???? ???????? ?????Ͽ???. ?????????? ???? ?????ϰ? ?ݿ??ϰ? ?ִ? ?????뷮 ?????? ?̻????? Ư???? ?????뷮 ?????? ?????Ͽ???. 
??. 74???? ???߸Ͱ?, ???????? 2/3/4?? ?ӻ????? 
???? ???ϰ? ?????? ?̻??????? ???? ?? ȫ??????. 
?ӻ?????(74???? ???߸Ͱ?, ???????? 2/3/4?? ????) ?? ?????? ???翡?? ?????? ?̻??????? ?Ʒ? [ǥ 1]?? ???? ?? ?????躰?? ???????? ???????? ?????? ?????Ͽ??? 
*?????? ???翡?? ?????? ?̻?????
?????뷮 ???? ?̻??? ?뷮????, ?̻??????? ???? ?????ϰ? ??Ÿ??????, ?Ϲ??????? ?? ?????ϰ? ?????Ǿ???.
??. ???Ʊ׶??? ?㰡?? ?ӻ????? 
1)6???? ?????뷮, ???౺ ???? ?ӻ????迡?? ?? ???? ???差???? ???????? ?? ?????? ???? ?̻??????? ?????Ǿ???.
?ð??̻?**: ???ϰ? ?Ͻ????? ???? ???? (?ַ?), ???????? ????, ?þ? ?帲. ?? ???????? ?? ?? ???? ȯ?ڸ??? ?ð??̻????? ???? ?ߴܵǾ?????, ?̷??? ?????? 100 mg ?Ǵ? ?? ?̻??? ???? ?? ???? ???? ???ϰ? ??Ÿ????.
2) 2% ?̻? ?߻??? ?̻????? ?? ???౺?????? ???? ?????? ??Ÿ?? ?̻??????? ?????? ????: ?⵵????, ??????, ???÷翣?? ???ı?, ??????.
3)?????뷮 ???????? ??ȭ?ҷ? (17 %) ?? ?ð??̻? (11 %) ?? 100 mg ?뷮???? ?? ?????? ?뷮???? ?????ϰ? ??Ÿ????. ?????뷮???? ???? ?뷮???? ?????? ???? ?̻????????? ??Ÿ?????? ?? ??? ?? ???Ҵ?. 
4)?????? ???? ?̻????????? 6???? ?????뷮, ???? ?ӻ? ???迡?? 2 % ?̸??? ȯ?ڿ??? ??Ÿ??????, ?? ?????? ?ΰ??????? ??Ȯ???? ?ʴ?. ?????? ?̻??????? ?๰ ?????? ???? ???ɼ??? ?ִ? ?͵??̰?, ?????? ?ִٰ? ???⿡?? ??Ȯ???? ???? ?????? ?̻????????? ???? ?Ͽ???.
(1) ????: ????, ?ȸ? ????, ???ΰ?????, ??ũ, ??????, ????, ????, ?쿬?? ????(accidental fall), ????, ?˷????? ????, ????????, ?쿬?? ?ܻ?
(2) ????????: ??????, ????????, ??????, ?ǽŢ?, ???Ƣ?, ?ɰ???????, ?????Т?, ü???? ??????, ?ɱ?????, ????????, ??????, ?ɺ???, ?????? ?̻?, ?ɱٺ???, ????Ȯ??.
(3) ??ȭ????: ??????, ??????, ????, ???忰, ???ϰ???, ????, ???忰, ?ĵ???, ??????, ??????????, ?????? ?̻?, ???? ????, ġ????.
(4) ???װ? ??????: ?????? ?????? ??????.
(5) ?????? ?? ??????: ????, ????, ??dz, ?Ҿ????? ?索??, ????????, ???ʺ???, ??????????, ????????, ????Ʈ??????.
(6) ???ݱٰ?: ??????, ??????, ????????, ???Ŀ?, ??Ȱ????, ??????, ?ٹ?????, Ȱ????.
(7) ?Ű???: ?????, ????????, ?Ű???, ?Ű溴??, ?????̻?, ????, ??????, ??????, ?Ҹ???, ??????, ?? ?̻?, ?ݻ????? ????, ????????.
(8) ȣ??????: õ??, ȣ??????, ?ĵο?, ?εο?, ?κ??, ????????, ????????, ??ħ????, ???.
(9) ?Ǻ? ?? ?μӱ???: ?ε巯??, ?ܼ?????, ??????, ????, ?Ǻα˾?, ?????Ǻο?, ??Ż ?Ǻο?.
(10)  Ư??????: ???۽??? û?°??? ?Ǵ? ??û, ?굿, ?ḷ??, ???νɢ?, ?̸?, ????????, ????, ??????, ?鳻??, ?ȱ?????????.
(11)  ????ı???: ?汤??, ?ߴ???, ????, ????Ȯ??, ???DZ?, ????????, ???ı? ???? ?? ?????̻???, ?????? ?̻?.
?ǵ????? ???????? ???? 1300 ??-?? (person-years)?̻?, ???? ???????? ???? 700 ??-?? (person-years)?̻??? ?????? ?̷????? ???߸Ͱ?, ???????? ?ӻ??????? ?м?????, ?ǵ??????? ?????? ȯ?ڱ??????? ?ɱٰ??????? ?߻????? ???????? ??ȯ?? ???? ???????? ?????? ???????? ȯ?ڱ??? ???????? ?? ???̰? ??????. ?ɱٰ??????? ??? ?ǵ??????? ???????? ȯ?ڱ??? ?????? ???????? ȯ?ڱ????? ???? 100 ??-?? (person-years) ?? 1.1?̾???. ???????? ??ȯ?? ???? ???????? ?? ?????? ???? 100 ??-?? (person-years) ?? 0.3?̾???.
5)?????ӻ????? ????, ȫ??, ????, ?ð??̻? ???? ?̻????? ?߻????? ?ܱ? ?ӻ????? ???????? ???ٴ? ?????? ?ִ?.
??. ???? ?? ????
1)?ɱٰ???, ???嵹????, ?ɽ? ??????, ???????? ????, ?Ͻ????? ?????? ???? ?? ?????? ???? ?ɰ??? ???????? ?̻??????? ?? ?? ?????? ?????Ͽ? ???? ?? ?Ͻ??????? ?????Ǿ???. ?? ȯ?? ?? ???κ??? ???????? ???????ڸ? ???? ?ִ? ȯ?ڿ????? ?̷??? ?̻????? ?? ?ټ??? ?????? ???? ?Ǵ? ???Ŀ? ?߻??Ͽ??? ?Ϻ??? ???? ?????? ???? ?? ?? ???? ???Ŀ? ?߻??? ?????? ?????Ǿ???. ?̿??? ???? ?? ???? ???? ?? ?????? ???? ???ð????? ???? ???̿? ?߻??Ͽ???. ?̷??? ?̻????????? ???? ?? ???? ?????? ?ִ???, ???????? ?????? ?ִ???, ??????ȯ???? ???? ?ִ? ?????? ??ȯ?? ?????? ?ִ???, ?̷??? ???ε??? ???յǾ? ?ִ??? ?Ǵ? ?ٸ? ???? ?????????? ???????? ?ʾҴ?. 
2)???? ?? ???۽??? û?°??? ?Ǵ? ??û?? ?幰?? ?????Ǿ??? ?̴? ?? ???? ?????? PDE5 ???????? ???????? ???????? ?ִ? ?????? ??Ÿ????. ?Ϻ? ???ʿ??? ??ȯ???¿? ?ٸ? ???ε??? û?°? ???õ? ?̻??????? ?????? ???? ???̶??? ?????? ?־?????, ???κ??? ???ʿ??? ?̷??? ???????? ?? ?? ?ִ? ?????? ???????? ???????? Ȯ?ε??? ?ʾҴ?. ?̷??? ?̻??????? ?? ???? ?????? ???????? ?????? ?ִ???, ȯ???? ???????? ??û ???????ڿ? ???? ??????, ?̵??? ???տ? ???? ?????? ?Ǵ? ?? ???? ?ٸ? ???ڿ? ???? ???????? ???????? ?ʾҴ?.
3)???? ?? ???Ƣ?, ?????Т?, ?ǽŢ??? ?????Ǿ???.
4)?幰?? ?ǵ??????? ??-???????? ?????????? ?? ???????? ?̻????? ?????? ?־???.
5)?? ???? ?????Ͽ? ???? ?? ?????? ??Ÿ ?̻????????? ?? ???? ???????? ?ΰ????谡 ??????, ?????? ?ӻ?? Ȯ?ε??? ???? ?̻??????? ?????? ????.
(1) ?Ű???: ?Ҿ???
(2) ????ı???: ?????? ?߱???, ????
(3) ?????? ?̻?: ???Ǣ?
(4) ????: ???ι?????
(5) ??: ????, ?Ͻ??? ?ð?????/?÷?????, ????, ?? ?ۿ???, ????â/?з?, ?ȱ??????? ????, ??????????ȯ ?? ????, ????ü ?ڸ?/???? ?? ?ٸ???Ȳ?? ????, ??????????????ýŰ???*
*??????????????ýŰ??? (Non-arteritic anterior ischemic optic neuropathy, NAION, ???????? ?÷? ?????? ?????? ?÷? ?????? ?????? ??) ?? ???? ?? ???翡?? ?幰?? ?????Ǿ???, ?̴? ?? ???? ?????? ???? PDE5 ???????? ???????? ???????? ?ִ? ?????? ??Ÿ????. ?ݵ??ô? ?ƴ?????, ???κ??? ȯ?ڵ??? ??????????????ýŰ????? ?????? ?? ?ִ? ?غ????? ?Ǵ? ???????? ???????ڸ? ?????? ?־???: ???? ?????Ը? ???? (low cup/disc ratio), 50?? ?̻??? ????, ?索??, ??????, ???????ȯ, ????????, ????. 
PDE5 ?????? ?迭 ?๰?? ?ֱ? ?????? ??????????????ýŰ??? ?޼? ?????? ???????? ???????? ???θ? ?????ϴ? ???? ???? ????, PDE5 ?????? ???? ?? ?ݰ????? 5?? ?ð? ?̳????? ??????????????ýŰ????? ?????? ?? 2?? ?????ϴ? ?????? ??Ÿ????. ??ǥ?? ???忡 ??????, ??????????????ýŰ????? ???? ?߻????? 50?? ?̻? ?Ϲ??? ???? 100,000 ?? ?? ???? 2.5-11.8???̴?.
6)???? ???? ?? ????????
(1) ?߱????? ȯ?? 8,751???? ???????? ?ǽ??? ???뼺?????? ???? 
?籹?????? ???ɻ縦 ???Ͽ? 8,751???? ???????? ?ǽ??? ???? ?? ???뼺?? ???????? ?????? ?ΰ????迡 ???????? ?̻????? ???????????? 6.62 % (579??, 701??/8,751??) ?? ??Ÿ??????, ?? ?? ?? ?????? ?ΰ????踦 ?????? ?? ???? ?̻??????? 6.21 % (543/8,751??) ?̾???. 
ȫ???? 3.75 % (328/8,751??)?? ???? ????????, ???? 1.83 % (160/8,751??), ??ȭ?ҷ? 0.23 % (20/8,751??), ??????, ?ɰ??????? ?? 0.22 % (19/8,751??), ?ȱ????? 0.15 % (13/8,751??), ?ð??̻? 0.11 % (10/8,751??) ???? ?????? ?????Ǿ???.
?? ?ۿ? 0.1% ???Ϸ? ?????? ?̻??????? ?????躰?? ?з??ϸ? ?????? ????.
- ???? ?? ???ʽŰ???: ??????, ȥ?? 
- ??ȭ????: ????, ????, ??????, ????, ????, ????, ???ϰ???, ???˾?, ???ĵ???????, ????????, ?????ظ?
- ??: ?þ?????, ????, ?ȱ? ??????
- ????????: ????, ????Ȯ??, ??????
- ȣ??????: ????, ??????, ȣ??????, ???⵵ ????
- ?? ?? ?㵵??: AST ????, ALT ????
- ???ŽŰ???: ?Ҿ?, ?Ҹ???, ????
- ???ı???: ???? ?߱???, ???ı? ????
- ??Ÿ: ?Լ??? ?Ӿ???, ????, ???ſ???, ?ȸ?????, ????????, ????, ?????̻?, ?Ƿ?, ???ܹ????? ????, ????, ȫ??, ??????, ??????
???? ?? ???? ?? ?ӻ????迡?? ??Ÿ???? ?ʾҴ? ???ο? ?̻????????? ?????? ?ΰ????踦 ?????? ?? ???? ?̻??????? ???ſ??? 3??, ??????, ȫ?? ?? 2??, ?Լ??? ?Ӿ???, ???˾?, ???ĵ???????, ????????, ???ܹ??????????? ?? 1?Ǿ? ?????Ǿ???.
 (2)?ڹ??? ?̻????? ???? ????
?籹?????? ???? ?? ?ڹ??????? ?????? ?̻????? ?? ???? ?? ?ӻ?? Ȯ?ε??? ?ʾ????? ???? ???? ?? ???翡?? ?? ?????? ???????? ?ΰ????谡 ?ִ? ?????? ??? ?̻????????δ? ?? ????, ???ӹ߱???, ?÷?????, ?ȱ??????? ????, ????, ??????????ȯ ?? ????, ?Ҿ?, ?Ͻ????? ?ð?????, ?????ڸ?, ??????, ????â, ?????? ?߱Ⱑ ??Ÿ????.
?豹?? ?̻????? ?????ڷ??? ?м?-??? ???? ?????? ?̻??????? ?߰??Ѵ?.
- ????: ?ȸ?ȫ??, ????/???ٱ?, ????????
- ?? ?? ?㵵??: ????/???̷???
- ????ı???: ????????, ?????财, ?ٴ???
- ??: ?쳻??, ????
- ?Ż???: ??????
- ?Ǻ?: ????
??. ?Ϻ??????? ?ӻ?
?㰡 ????, ?? ?? (?????? ?????? ?뷮: 25mg - 50mg) ?? ?????? 157???? ?????? ?? 40?? (25.48 %) ???Լ? ?̻??????? ?????Ǿ????? 31?? (19.75 %) ???Լ? ?ӻ? ?????? ?˻??? ?̻??? ?????Ǿ???.
???? ?????? ?̻??????? ????(20??; 12.74%), ȫ??(16??; 10.19%), ?ð??̻?(?????? 1??, ?????????? 1??, ?ḷ?? 1??: ?? 3?? 1.91%) ???̴?. ???? ?????? ?ӻ? ?????? ?˻??? ?̻??? ũ????ƾŰ??????(CK) ?????̸? ?ǵ??????? ???? ???? 132?? ?? 9?? (6.82%) ???? ?????Ǿ???.
?????? ?̻??????? ?????? ȯ?ڴ? ?ʿ??? ???? ?๰???? ?뷮?? ???̰ų? ?????? ?ߴ??ؾ? ?ϸ? ?̻??????? ġ???ϱ? ???? ?????? ??ġ?? ???ؾ? ?Ѵ?.
1): ?ڹ??? ???? ?????? ???? ??? ?? ?? ???? ????
2): ?ΰ????谡 Ȯ???????? ?ʾ?????, ?? ???? ?????? ?? ?ɱٰ????? ?߻??ߴٴ? ???? ?? ?????? ?־???
5. ?Ϲ??? ????
1)?? ???? ???? ????ȯ?ڴ? ?߱????? ?? ??????ȯ?? ?????ϱ? ???? ?????? ?????ϰ? ?˻縦 ???Ͽ? ???????? ?????? ?ٰŷ? ?ӻ?ġ?ᰡ ?ʿ??? ȯ?ڷ? ?????Ͽ??? ?Ѵ?.
2)???????? ?????? ?????? ?????ϱ? ?????? ġ?Ḧ ?????ϱ? ???? ???????? ???¿? ???Ǹ? ???￩?? ?Ѵ?. ?? ???? ????Ȯ???ۿ뿡 ???? ???а????ۿ??? ???? ?ֱ? ?????? ???꿰 ?Ǵ? NO ???????? ???а????ۿ??? ??????ų ?? ?ִ?.
3)?ֱ? 6???? ?̳??? ??????, ??????, ?ɱٰ????? ?????? ȯ?ڴ? ???????? ???ƾ? ?ϸ? ?? ?????? ??????, ??????, ?ɱٰ????? ?????? ?ִ? ȯ?ڿ??? ?????? ???? ???????? ??ȯ?? ???? ???? ?????? Ȯ???Ͽ??? ?Ѵ?.
4)?ǵ??????? ???????? dz???? ?????? ???? ???? ģȭ???? ???̴? ???? ???????迡?? ?????Ǿ??? ??????, ?? ?๰?? ???Ⱓ ?????ϴ? ???? ?Ȱ??? ?˻縦 ?????ϴ? ?? ???Ǹ? ???￩?? ?Ѵ?.
5)???? ?? ?????????ɷ¿? ??ġ?? ????: ?ӻ????迡?? ?? ???? ?????? ???? ȯ?ڿ???, Ư?? 100 mg ?????? ?? ?? ?????? ???? ?ð? ?̻?, ???????? ?????Ǿ????Ƿ? ?????̳? ???? ???? ?? ?????Ͽ??? ?Ѵ?. ȯ?ڰ? ???? ?Ǵ? ?????????? ?ϱ? ???? ȯ?ڵ??? ?ڽ??? ?? ?࿡ ??? ?????ϴ??? ?? ?˾ƾ? ?ϸ?, ?ǻ??? ?̿? ???? ?????? ?ؾ? ?Ѵ?. 
6)???????????? ???? ?ް? ?ִ? ȯ?ڿ??? ?? ???? ???ÿ? ?????ϴ? ???? ?Ϻ? ȯ?ڿ??? ?幰?? ???ļ? ???????? ?????? ?? ?ִ?. ?׷??Ƿ? 25 mg?? ?ʰ??ϴ? ?? ???? ???????????? ?????ϴ? ???쿡?? ?? ???? ?????????? ???? ?? 4?ð? ?̳??? ?????ؼ??? ?ȵȴ?. ?̷??? ü???? ???????? ?????? ?ּ?ȭ?ϱ? ???Ͽ? ?? ???? ó?? ?????ϱ? ???? ȯ?ڰ? ???????????? ???׵??????????? ???????? Ȯ???Ͽ??? ?ϸ?, ??ȸ ?뷮?? ???뷮???? ?????? ???? ?????ϵ??? ?Ѵ?. ????, ?ǻ??? ü???? ???????? ?????? ??Ÿ???? ??? ??ó?? ?????? ȯ?ڿ??? ?˷??ֵ??? ?Ѵ?. 
7)?๰ ??ȣ?ۿ? ????????, ?Ϸε??? 5 mg, 10 mg?? ?? ?? 100 mg?? ?????? ȯ?ڿ??? ???? ?????? ???? ?̿ϱ? ???а? ?????? ?????? ???? ???? 7 mmHg, 8 mmHg?? ?????? ???? ?????Ǿ???. ?? ???? ?ٸ? ?????? ġ???? ???? ?๰??ȣ?ۿ뿡 ???? ?????? ???????? ?ʾҴ?. 
8)?? ???? ?ܵ????? Ȥ?? ?ƽ??Ǹ??? ?Բ? ?????? ???? ?????ð??? ?ƹ? ?????? ??ġ?? ?ʾҴ?. ???? ???????? ?̿??? ???????? ?????? ?ǵ??????? ??Ʈ???????õ峪Ʈ???? ?????? ȿ???? ??????Ŵ?? ???? ?ش?. ?? ???? ???ĸ??? ?????? ?????? ?䳢???? ?????ð??? ???? ???????? ?????? ??ġ??, ?̷??? ??ȣ?ۿ??? ?????????? ???????? ?ʾҴ?.
9)ȯ???? ?? (???? ?Ǵ? ???? ??) ?? ???۽??? ?÷? ?????? ?߻??ϴ? ????, ?ǻ??? ?? ???? ?????? PDE5 ???????? ?????? ?????? ???? ȯ?ڿ??? ?ǰ??ϰ? ???????? ???Ǹ? ???￩?? ?Ѵ?. ?̷??? ?????? ??????????????ýŰ??? (Non-arteritic anterior ischemic optic neuropathy, NAION, ???????? ?÷? ?????? ?????? ?÷? ?????? ?????? ??)?? ¡?İ? ?? ?? ??????, ?̴? ???? ?? ???翡?? ?幰?? ?????Ǿ???, ?? ???? ?????? ????PDE5 ???????? ?????? ???????? ???????? ?ִ? ?????? ??Ÿ????. ???۽??? ?÷? ?????? ??Ÿ???? ????, ?? ???? ?????? ?????ϰ? ???? ?ǻ??? ?????ϵ??? ȯ?ڿ??? ?˷??? ?Ѵ?. 
??????????????ýŰ????? ?̹? ?????? ???? ?ִ? ?????? ????, ??????????????ýŰ????? ???? ?????? ?????? ?? ????. ?????? ?ǻ??? ?̷??? ???輺?? PDE5 ???????? ???뿡 ???? ?̻????? ?߻??? ?????? ???? ?? ?????? ?̵? ȯ?ڿ??? ?˷??? ?Ѵ?. ?̷? ȯ?ڵ鿡?? ?? ???? ?????? PDE5 ???????? ?????? ?????? ???Ǹ? ???￩?? ?ϸ?, ?????Ǵ? ???ͼ??? ???輺?? ??ȸ?ϴ? ???쿡?? ?????ؾ? ?Ѵ?. 
10)???۽??? û?°??? ?Ǵ? ??û (?̸??? ???????? ???ݵ? ?? ????) ?? ?߻??ϴ? ????, ?ǻ??? ?? ???? ?????? PDE5 ???????? ?????? ?????? ???? ȯ?ڿ??? ?ǰ??ϰ? ???? ???????? ???Ǹ? ???￩?? ?Ѵ?.
11)?? ???? ???????? ???????????? ?ƴϹǷ? ?߱????? ȯ???? ġ?????? ?̿ܿ??? ?????? ?? ????.
12)???Ĺ??? ?Բ? ?????? ???? ???? ?ÿ? ?????ϴ? ???캸?? ȿ???????ð??? ?????? ?? ?ִ?. 
13) ?? ???? ?????? ???????? ?????Ǵ? ??ȯ?? ?????? ?? ????.
14) ?? ???? ?ٸ? PDE5??????, ?ǵ??????? ?????? ??ư?????(PAH) ġ????, ?Ǵ? ?ٸ? ?߱????? ġ?????? ???????????? ?????? ?? ??ȿ???? ???? ?????? ???????? ?ʾ?????, ?̷? ?????????? ???????? ?ʴ´?. 
6. ??ȣ?ۿ?
1)?? ???? ???߳?? ??????Ű?? ?๰
(1) ???????? ???????? ?ǵ??????? ?????? ?ַ? CYP3A4 (?ְ???) ?? 2C9 (?ΰ???)?? ???? ?Ű??ȴ?. ?׷??Ƿ? ?̷??? CYP-450 ???????? ?ǵ??????? ???? ??? ??????ų ?? ?ִ?. 
(2) ü?????????? ??Ư???? CYP-450 ???????? ?ø?Ƽ??(800 mg) ?? ?ǰ??? ?ڿ??ڿ??? ?? ?? (50 mg) ?? ?????????? ???? ?ǵ??????? ??????? 56% ???????״?. 
(3) ?? ???? 100 mg ??ȸ?뷮?? ?ߵ CYP3A4???????? ????Ʈ?θ??̽? (500 mg, 1?? 2ȸ, 5??)?? ???????¿??? ?????? ???? ?ǵ??????? ???ų???(AUCġ)?? 182 % ???? ???״?. ?̿ܿ???, ?ǰ??? ???? ?????ڸ? ???????? ?̷????? ???????? CYP3A4 ???????? HIV protease ?????? ????????? ???? ?? ???????¿??? (1,200 mg, 1?? 3ȸ) ?? ??(100 mg, ??ȸ ????)?? ?????? ?? ?ǵ??????? Cmax?? AUC?? ???? 140 %, 210 % ?????Ͽ?????, ?????ڳ???, ??Ʈ???ڳ????? ???? ?? ?????? CYP3A4 ???????? ?? ū ?????? ??ĥ ?? ?ִ?.
(4) ?ӻ?????? ȯ?ں? ?????? ?ڷ??? ?????ڳ???, ????Ʈ?θ??̽? ?Ǵ? ?ø?Ƽ?? ???? ???? CYP3A4 ???????? ?????????? ???? ?ǵ????? û?????? ???Ҹ? ??????. 
(5) ?ǵ????ʿ? ???? ???? ???⵵?? CYP3A4 ???????? ???? ???? ?? ?????ϹǷ?, ???༺?? ???? ?? ???? ?????뷮?? ?????Ͽ??? ?? ???? ?ִ?.
(6) HIV protease ???????? ???䳪??? ?ſ? ?????? CYP-450 ???????μ? ?ǰ??? ???? ?????ڸ? ???????? ?? ???????? ?????????? ??(500 mg, 1?? 2ȸ) ?? ??(100 mg, ??ȸ ????)?? ?????? ???? ?ǵ??????? Cmax?? AUC?? ???? 300 %(4??), 1000 %(11??) ?????Ͽ???. ?ǵ??????? ?ܵ????? ?? ??????? ?? 5 ng/mL?? ?Ͱ? ?????Ͽ? 24?ð? ?Ŀ??? ??????? ?? 200 ng/mL?? ?????Ͽ???. ?̰??? ???䳪??? ???????? ?????? CYP-450 ?????? ???? ?ѷ??? ?????? ??ġ?? ???ǰ? ??ġ?ϴ? ???̴?.
(7) ?ٸ? protease ???????? ?? ?? ?????? ??ȣ?ۿ??? ?????? ?? ?????? ???????? ?? ?ǵ??????? ???߳??? ?????? ?????ȴ?. 
(8) ?????? CYP3A4 ???????? ???? ???? ȯ?ڿ??? ???? ?뷮?? ?ǵ??????? ?????? ????, ? ȯ?ڿ????? ?ǵ??????? ?ְ? ???? ???? ??? 200 nM?? ???? ?ʾ????? ?׻? ???༺?? ??ȣ?Ͽ???.
(9) ?ǰ??? ???? ?????ڸ? ?????????? ???迡??, ?????ڸ? ???????? ????ź(CYP3A4 [?ߵ], CYP2C9 ???????̸? ?? ?Ƹ??? CYP2C19 ??????)?? ????????(125 mg 1?? 2ȸ ????)???? ?????????? ?ǵ????? (80 mg 1?? 3ȸ ????)?? ???? ??, ?ǵ???????AUC ?? Cmax?? ???? 62.6% ??55.4% ???ҵǾ???. ?ǵ??????? ????ź??AUC ??Cmax ?? ???? 49.8% ??42%???? ???????״?. 
(10) ?????ɰ? ???? ??????CYP3A4 ???????? ???????? ?? ???? ?ǵ????? ?????????? ?????? ???Ұ? ?????ȴ?.
(11) ??????(????ȭ???׳׽?/????ȭ?˷??̴?)?? ??ȸ ?????? ?? ???? ??ü?̿????? ?????? ??ġ?? ?ʾҴ?. 
(12) ???? ?????? ?ڷ? ?м?????, ????Ÿ???̵?, ?͸??ĸ??? ???? CYP2C9 ?????? ?? SSRI ????(?????? ???????? ?????? ??????), ??ȯ?? ?׿??????? ???? CYP2D6 ??????, Ƽ?????? ?? ?? ?迭?? ?̴???, ACE ?????? ?? Į?? ???? ?????????? ?ǵ??????? ?๰?????п? ?ƹ??? ?????? ??ġ?? ?ʾҴ?. Ȱ?????繰?? N-??????ƿ ?ǵ??????? AUC?? loop ?̴??? ?? Į?????? ?̴????? ???? 62 % ?????Ǿ??? ??Ư???? ??Ÿ???????? ???? 102 % ?????Ͽ???. ?????깰?? ???? ?̷??? ?????? ?ӻ??? ???Ǽ??? ?ִ? ?????? ?????? ?ʴ´?.
(13) ?ǰ??? ???? ?????ڿ???, ????Ʈ?θ??̽?(1?? 500 mg?? 3?ϵ??? ????)?? ?ǵ????? ?Ǵ? ?ǵ??????? ?ֿ? ??ȯ????ü?? AUC, Cmax, Tmax, ?ҽǼӵ? ????(elimination rate constant) ?? ?ݰ??⿡ ?????? ??ģ?ٴ? ???Ŵ? ????.
(14) ?ǵ????ʰ? ??Ŭ?ν??????? ??ȣ?ۿ뿡 ???? ?????? ????.
 2)?ٸ? ?๰?? ???? ?? ???? ????
(1) ???????? ???????? ?ǵ??????? CYP-450 isoform 1A2, 2C9, 2C19, 2D6, 2E1 ?? 3A4(IC50: > 150 ??M)?? ?ణ ?????ϴ? ???????̴?. ?????뷮 ???? ?? ?ǵ??????? ?ְ? ???? ??? ?? 1 ??M???? ?????ϸ? ?? ???? ?̷??? ????ȿ?? ?????? û?????? ??ȭ??ų ???ɼ??? ????.
(2) ü??????????, ?????? ȯ?ڿ??? ?? ?? 100 mg?? ?Ϸε??? 5 mg, 10 mg?? ?????????? ???? ???? ?ڼ? ???п? ???? ???????? ?̿ϱ? ???? ???? 8 mmHg, 7 mmHg ?????Ͽ???. 
(3) ?? ???? ?׿??ʸ? ?Ǵ? ???Ǹ??ٸ??? ???? ??Ư???? PDE ?????????? ??ȣ?ۿ뿡 ???? ?????? ????.
(4) ü??????????, CYP2C9?? ???? ?????Ǵ? ????Ÿ???̵?(250 mg)?? ?͸??ĸ?(40 mg)?? ?????? ???? ?๰??ȣ?ۿ??? ?????? ?ʾҴ?. 
(5) ?? ??(50 mg)?? ?ƽ??Ǹ?(150 mg)?? ???? ???ߵ? ?????ð??? ?????? ??????Ű?? ?ʾҴ?. 
(6) ?ǵ??????? ???? ???ڿ? ?????? 80 mg/dL?? ?ǰ??? ?????ڿ??? ???? ?ڼ? ?? ?????? ?ڼ??? ?̿ϱ? ?????? ?ణ ???ҽ?Ų?? (???? 3.5 ?? 6.1 mmHg). 
(7) ?ǵ?????(100 mg)?? ?ǰ??? ?????????ڿ? ???? ???????? CYP3A4?? ???? ?????? HIV protease ?????? ????????? ???䳪?????? ???????¿????? ?๰???¿? ?????? ??ġ?? ?ʾҴ?. 
(8) ?ǵ??????? ???????¿???(80 mg 1?? 3ȸ ????) ????ź(125 mg, 1?? 2ȸ ????)?? AUC ?? Cmax?? 49.8%, 42%???????״? ( 1) ?? ???? ???߳?? ??????Ű?? ?๰ ????).
3)?????????? ?????ް? ?ִ? ?缺 ???????????? ȯ?ڸ? ???????? ???????????? ???????? (4 mg ?? 8 mg) ?? ?ǵ????? (25 mg, 50 mg ?Ǵ? 100 mg) ?? ???ÿ? ?????? ????, ???? ?ڼ??????? ?????? ???? ???? 7/7 mmHg, 9/5 mmHg, 8/4 mmHg?? ?? ???ҵǾ??? ?? ?ִ? ?ڼ??????? ?????? ???? ???? 6/6 mmHg, 11/4 mmHg, 4/5 mmHg?? ?? ???ҵ? ???? ?????Ǿ???. ?????????? ?????ް? ?ִ? ȯ?ڿ??? 25 mg???? ?? ???뷮?? ?ǵ??????? ???ÿ? ?????? ????, ?๰???? ?? 1?ð? ???? 4?ð? ?̳??? ????, ???????? ?????? ???ļ? ü???? ???????? ?????? ȯ?ڵ??? ?幰?? ?????Ǿ????? ?ǽ??? ???????? ?ʾҴ?.
4)ī???丮Ƽ?????? ???뿡 ???? ???а????ۿ??? ?????? ?? ?ִ?.
5)?ƹ̿??ٷп??꿰?? ???? QTc???? ?ۿ??? ?????? ?? ?ִ?.
7.?Ӻ? ?? ?????ο? ???? ????
1)?? ???? ???????? ?????? ?? ????. 
2)?????????Ⱓ ?? 200 mg/kg/day?? ?ӽ? ???忡 ?????ÿ??? ???????? ?????????? ü???? ?????Ͽ?????, ?? ?뷮?? ??ü?? ???? ?ִ? ???? ?뷮?? 100 mg?? ???????? ?????Ͽ??? ?? ?????? ???ⷮ?? 60?? ?̻??? ?ش??ϴ? ?????? ?ǵ????? ?? ?? ?ֿ? ????ü?? ???? ?? ???? ?๰ ???ⷮ?? ??Ÿ??????.
3)???带 ?̿??? ?ֻ??????? ???迡?? 60 mg/kg ?????? ?ѹ????????? ?????Ͽ?????, ???忡 ???? ?ֻ??? ?? ?????? ?ߴ? ???迡?? ?̻??????? ???????? ?ʴ? ?ִ? ?뷮?? 30 mg/kg/day?? 36?ϰ? ?????? ???̾???. ?ӽ????? ???? ???忡??, ?? ?뷮?????? AUC?? ???????? ?????? AUC?? ?? 20?迴??.
4)?Ӻ? ?? ?????ο? ???? ?????? ?????? ????.
8. ?Ҿƿ? ???? ????
?? ???? ?Ż???, ??18?? ?????? ?Ҿƿ??? ?????? ?? ????(??2. ????ȯ?ڿ??? ???????? ?? ?͡? ????).
9.?????ڿ? ???? ????
?????? ?ǰ??? ??????(65?? ?̻?)???? ?ǵ??????? û?????? ?????Ͽ???. ???? ??? ???? ???? ȿ???? ?̻????? ???????? ???? ?????? ?? ?????Ƿ? ??ȸ ?뷮???? 25 mg?? ?????Ǿ??? ?Ѵ?. 
10.???????????? óġ
1)?ǰ??? ?????ڿ? ???? ???????? ?ְ? 800 mg???? ??ȸ ?????? ???? ?̻??????? ???뷮 ???????? ?̻??????? ?????Ͽ????? ?̻????? ?߻??? ?? ???????? ?????Ǿ???. 200 mg?? ???????? ?? ȿ???? ???????? ?ʾ????? ?̻????? (????, ȫ??, ??????, ??ȭ?ҷ?, ?ڸ???, ?ð??̻?) ?߻????? ?? ?????? ?????? ?????Ͽ???. 100 mg?? ???????? ?? ?̻??????? ??? ???? ?뷮?? 25 - 50 mg ???????? ?????? ?ͺ??? ???Ҵ?. 
2)?????????? ???? ?????????? ?????Ͽ??? ?Ѵ?. ?ǵ??????? ???? ?ܹ????????? ???? ???? ?輳???? ?????Ƿ? ???????????? û??ġ?? ??????Ű?? ???Ѵ?.
11.???? ?? ???޻??? ???ǻ???
1)????? ???? ???? ?ʴ? ???? ?????Ѵ?. 
2)?ٸ? ???⿡ ?ٲپ? ?ִ? ???? ?????????? ?ǰų? ǰ?? ?????鿡?? ?ٶ??????? ?????Ƿ? ?̸? ?????Ѵ?. 
12. ??Ÿ
1)?ǵ????? ?? ?? ?????깰?? ???? ?? ???ž๰???? (AUCs) ?? ?־? ?ǵ??????? ?ְ? ???差?? 100 mg ???? ?? ?????? ???⺸?? ???? 29?? ?? 42?迡 ?ش??ϴ? ?뷮???? ?????? ???? ?? ???ƿ??? 24???? ???? ???????? ?? ?߾ϼ??? ?????? ?ʾҴ?. 
2)?ǵ??????? üǥ????(mg/m2) ???? ??ü ?ְ? ?????뷮?? ?? 0.6?迡 ?ش??ϴ? 1?? kg ?? 10 mg?? ?ְ??????뷮(MTD)???? ???콺???? 18-21???? ???? ???????? ?? ?߾ϼ??? ?????? ?ʾ?????, ?ǵ????? ?? ?ִ????깰?? ?? ???ų??ⷮ?? ?ְ? ?????뷮?? ???????? ???? ?? ?????? ???ⷮ???? ???? ??Ÿ????. 
3)???带 ???????? ?? 1???????? ?汸 ???? ???迡??, 45 mg/kg?? 200 mg/kg ?뷮???? â?? ???? ???ƿ? (mesenteric arteritis) ?? ?????Ǿ???. ?׷???, ???带 ???????? ?? 6???? ?? ?????????? ?߾ϼ? ???迡???? ???????? ?ʾҴ?. ???۰??? ???????? ?? 6?????? 12?????? ???? ?汸 ???? ???迡?? ?ְ? ?뷮?? 50 mg/kg?? ???????? ?? ???ƿ??? Ư?߼? ???? ?ٹ߼????ƿ? (idiopathic juvenile polyarteritis) ?? ?????Ǿ???. ?̷??? ??ȭ?? ???????Ե? ?????? ???ɼ??? ???? ?????? ?????ȴ?.
4)?ǵ??????? ???̿????? ?????ϱ? ???? ???????? ???ս??? ?? ?߱??? ?ܽ????? ???? ???? ?м????? ?? ????ü?̻? ???߼??? ?????ϱ? ???? ???????? ???? ?????????? ?? ü?? ???콺 ???? ???迡?? ?????̾???. 
5)???? AUC?? 25?? ?̻??? AUCġ?? ?ش??ϴ? ?뷮?? 1?? kg?? 60 mg?????? ?뷮?? ???ƿ??? 36??, ???ƿ??? 102?? ?????? ???? ???Ĵ??? ???ϸ? ?????? ?ʾҴ?. 
6)?ǰ??? ???? ?????ڿ??? 100 mg ??ȸ ?뷮 ?汸???? ?? ?????? ??? ?Ǵ? ???¿? ?ƹ??? ?????? ??ġ?? ?ʾҴ?.
7)?߱????? ȯ???? ???׻??? ?? ???ڿ??/???¿? ???? ?ǵ??????? ???⿡ ???? ?????? ????.



Remen`s ĢĢ?? 2+2??
???Ʊ׶?100mg 8??+8??
???н?Vinix 1+1?ڽ?(20pack)
????ų 1??
??Ʈ?? 1+1?ڽ?(20pack)
???дϽ? ?ö??? 2+2??
??Ʈ??ŷ?? 2?? 200ȯ
????????(D8) 2+2??
????????1+1??(20??)
???????? Ȯ???? 1+1??


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